Research result: pharmacology and clinical pharmacology

Issue №1 (1) 2015
EXPERIMENTAL PHARMACOLOGY

CONCOMITANT USE OF STATINS AND S-(2-BORON-ETHYL)-L-CYSTEINE ARGINASE INHIBITOR TO CORRECT ENDOTOXIN-INDUCED ENDOTHELIAL DYSFUNCTION

The concomitant use of non-selective S-(2-boron-ethyl)-L-cysteine (BEC) arginase inhibitor with simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of endotoxin-induced disorder modeling by Staphylococcus aureus (strain 13407) injection under ...

HUMAN RECOMBINANT ERYTHROPOIETIN GRADIENT DOSAGE INFLUENCE ON ISCHEMIC AND REPERFUSION LIVER INJURY

We investigate influence of human recombinant erythropoietin different dosage on blood flow velocity and morphological changes in liver during ischemic and reperfusion injury. It was proved what optimal preconditioning dosage ...

USE OF SELECTIVE INHIBITORS OF ARGINASE 2 AND TADALAFIL IN COMBINED COMPENSATION OF HOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION

Use of selective inhibitors of arginase 2 in combination with tadalafil on in the course of modeling of homocysteine-induced endothelial dysfunction provided endotelio- and cardioprotective effects manifested in preventing of ...

ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN

TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies ...

PHARMACOLOGICAL PROTECTION OF THE ISCHEMIC MYOCARDIUM BY DERIVATIVES OF 3-(2,2,2-TRIMETHYLHYDRAZINIUM) PROPIONATE AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY

The paper presents results of a study of antioxidant (in vitro) and anti-ischemic effect of a number derivatives of 3-(2,2,2-trimethylhydrazinium) propionate. It was revealed that among other compounds 5-hydroxynicotinate of ...

THE STUDY OF OSTEOPROTECTIVE PROPERTIES OF NANOPARTICULATED FORMS OF RESVERATROL AND LOSARTAN

The study demonstrated that endothelial dysfunction of bone microvasculature and deterioration of regional blood flow in bone developed eight weeks after ovariectomy in female white Wistar rats thus raising the ...

THE EFFECT OF HUMORAL FACTORS RELEASED BY HYPOPERFUSED PLACENTA ON FETAL DEVELOPMENT

Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of ...

PROPERTIES OF NANO ENCAPSULATED L-ARGININE AND RESVERATROL IN WATER-SOLUBLE POLYMERS

This article analyzes properties of nano encapsulated L-arginine and resveratrol using a Nanoparticle Tracking Analysis method, and studies their supramolecular properties using a self-organization method.

ISCHEMIA/REPERFUSION EFFECT ON PANCREATIC VOLUMETRICAL BLOOD FLOW VELOCITY

We investigate blood flow velocity at ischemia/reperfusion early stages. Transient hyperemia absence after ischemia/reperfusion cased by pancreatic edema development at early stages confirmed by Wet/Dry ratio elevation and morphological changes ...

STUDY OF THE MICROCIRCULATION LEVEL IN BONE WITH OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES DURING THERAPY WITH RECOMBINANT ERYTHROPOIETIN, ROSUVASTATIN AND THEIR COMBINATIONS

The experiment was carried out in female white Wistar rats. The effects of recombinant erythropoietin, rosuvastatin and their combination were investigated based on the blood supply to the bone after ...

CLINICAL PHARMACOLOGY

ASSESSMENT OF SENIOR DENTAL STUDENTS AND DENTAL RESIDENTS IN MATTERS OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial therapy (AMT) is one of the principal problems in practice of the modern dentist. Mass visits to doctors for dental care, the prevalence of dental diseases among people from ...

PANCREATOGENIC INFECTIONS: IMPORTANCE OF MICROBIOLOGICAL MONITORING AND PENETRATION OF ANTIMICROBIAL CHEMOTHERAPEUTIC AGENTS INTO THE PANCREAS WHEN DEFINING THERAPEUTIC APPROACH

The review provides the information on the spectrum of microorganisms initiating the development of clinical and morphological forms of pancreatogenic infections. It is shown that when analyzing pathological conditions, no ...