Research result: pharmacology and clinical pharmacology

Issue №1 (2) 2016
EXPERIMENTAL PHARMACOLOGY

ENDOTHELIUM AND CARDIOPROTECTIVE EFFECTS OF HMG-CO-A-REDUCTASE IN COMBINATION WITH L-ARGININE IN ENDOTHELIAL DYSFUNCTION MODELING

Abstract. Using the combined application of L-arginine with HMG-Co-A reductase inhibitors simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of modeling of sepsis-induced disease through the introduction of strain ...

ENDOTHELIOPROTECTIVE PROPERTY OF THE COMBINATION OF THE THIOCTIC ACID AND ROSUVASTATIN SHOWN IN THE ENDOTHELIAL DYSFUNCTION MODELS

During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same ...

ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA

The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg ...

USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION

For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environment. ...

PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED OXIDE DEFICIENCY WITH DERIVATIVES OF 3-(2,2,2- TRIMETHYLHYDRAZINIUM) PROPIONATE

This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have shown that 3-(2,2,2-trimethylhydrazinium) propionate and its derivatives reduced the expression ...

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This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The ...

CLINICAL PHARMACOLOGY

DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range ...
MOLECULAR SCREENING

TEST-SYSTEM FOR ESTIMATION OF ACTIVITY OF GSK-3 INHIBITORS AS ANTIHYPOXANTS AND DIFFERENTIATION OF ENDOTHELIAL PROGENITORS IN VITRO

A model test-system was developed for validation in vitro of antihypoxic and endothelio-differentiating activity of newly created glycogen synthase kinase-3 inhibitors in comparison with the reference drug β4-thymosin.

MOLECULAR SCREENING OF PROSPECTIVE CANDIDATES FOR TRPA1 ION CHANNEL SELECTIVE ANTAGONISTS

TRPA1 is an ankyrin receptor of TRP family. It is mostly expressed in the smalldiameter nociceptors with cell bodies located in the dorsal roots, as well as in trigeminal, nodose ...