Research result: pharmacology and clinical pharmacology

Issue №1 (2) 2016
EXPERIMENTAL PHARMACOLOGY

ENDOTHELIUM AND CARDIOPROTECTIVE EFFECTS OF HMG-CO-A-REDUCTASE IN COMBINATION WITH L-ARGININE IN ENDOTHELIAL DYSFUNCTION MODELING

Denisyuk Tatiana Alekseevna, Lazareva Galina Anatol'evna, Provotorov Vladimir Yakovlevich, Shaposhnikov Andrey Aleksandrovich
Abstract. Using the combined application of L-arginine with HMG-Co-A reductase inhibitors simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of modeling of sepsis-induced disease through the introduction of strain ...

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ENDOTHELIOPROTECTIVE PROPERTY OF THE COMBINATION OF THE THIOCTIC ACID AND ROSUVASTATIN SHOWN IN THE ENDOTHELIAL DYSFUNCTION MODELS

Olga Viktorovna Molchanova, Tatyana Grigorevna Pokrovskaya, Sergej Vladimirovich Povetkin, Konstantin Mihajlovich Reznikov
During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same ...

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ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA

Vladimir Y. Provotorov, Michael V. Korokin, Mikhail V. Pokrovskii, Sergej V. Povetkin, Galina A. Lazareva, Aleksandr A. Stepchenko, Natalya A. Bystrova
The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg ...

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STUDY OF THE INFLUENCE OF L-NORVALINE, ROSUVASTATIN AND THEIR COMBINATION ON THE LEVEL OF MICROCIRCULATION IN BONE TISSUE IN EXPERIMENTAL OSTEOPOROSIS AND FRACTURES ON ITS BACKGROUND

Densingh Samuel Raj Rajkumar, Oleg Sergeevich Gudyrev, Alexander Vladimirovich Faitelson, Aleksandr Aleksandrovich Stepchenko, Alexander Anatolievich Dolzhikov, Sergej Vladimirovich Povetkin
The experiment was carried out in female white Wistar rats to investigate the effect of L-norvaline, rosuvastatin and their combination on parameters of blood supply to the bone tissue on ...

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PHARMACOLOGICAL PRECONDITIONING BY RECOMBINANT ERYTHROPOIETIN AS THE POSSIBILITY OF INCREASING THE STABILITY OF TISSUE OF THE RETINA TO REPERFUSION ISCHEMIA IN EXPERIMENT

Anna S. Shabelnikova, Anna A. Peresypkina, Viktoriya O. Gubareva, Elena A. Levkova, Alexander A. Dolzhikov, Sergej B. Nikolaev, Aleksandr A. Stepchenko
Ischemic injury was formed in laboratory rats by applying mechanical pressure (110 mm Hg) to the anterior eye chamber for 30 minutes. The experiment revealed that the recombinant erythropoietin (50 ...

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USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION

Ekaterina Alexandrovna Shakhno, Tatyana Alexandrovna Savitskaya, Tatyana Grigorevna Pokrovskaya, Vladimir Ivanovich Yakushev, Mikhail Vladimirovich Pokrovskii, Dmitry Davidovich Grinshpan
For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environment. ...

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PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED OXIDE DEFICIENCY WITH DERIVATIVES OF 3-(2,2,2- TRIMETHYLHYDRAZINIUM) PROPIONATE

Sophia Y. Skachilova, Oleg G. Kesarev, Lyudmila M. Danilenko, Natalya A. Bystrova, Alexander A. Dolzhikov, Sergej B. Nikolaev
This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have shown that 3-(2,2,2-trimethylhydrazinium) propionate and its derivatives reduced the expression ...

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Vladimir I. Yakushev, Nikolaj G. Filippenko, Irina V. Kizilova, Michael V. Korokin, Evgeniya A. Beskhmelnitsyna, Anna S. Litvinova
This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The ...

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CLINICAL PHARMACOLOGY

ANALYSIS OF DYNAMICS OF ANTIBIOTIC RESISTANCE OF PATHOGENS IN PATIENTS WITH DIABETIC FOOT SYNDROME UNDERGOING IN-PATIENT TREATMENT

Galina A. Batishcheva, Tatyana N. Malorodova, Tatyana G. Pokrovskaya, Elena E. Каzаkоvа, Janna S. Urojevskaya, Nina I. Zhernakova, Ol'ga A. Osipova
Persistent ulcers in patients with diabetic foot syndrome in 85% of cases lead to amputation because of secondary infection and growing gangrene that significantly worsen the prognosis. In the course ...

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DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

Andrey A. Buzov, Aleksandr L. Kulikov, Tatyana V. Avtina, Mikhail V. Pokrovskii, Ol'ga A. Osipova
We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range ...

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MOLECULAR SCREENING

TEST-SYSTEM FOR ESTIMATION OF ACTIVITY OF GSK-3 INHIBITORS AS ANTIHYPOXANTS AND DIFFERENTIATION OF ENDOTHELIAL PROGENITORS IN VITRO

Youri E. Burda, Sergey V. Nadezhdin, Ekaterina V. Zubareva, Mikhail V. Pokrovskii, Alexander V. Faitelson, Svetlana Y. Burda, Maria S. Shirina
A model test-system was developed for validation in vitro of antihypoxic and endothelio-differentiating activity of newly created glycogen synthase kinase-3 inhibitors in comparison with the reference drug β4-thymosin.

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MOLECULAR SCREENING OF PROSPECTIVE CANDIDATES FOR TRPA1 ION CHANNEL SELECTIVE ANTAGONISTS

Dmitrii V. Kravchenko, Evgeniya A. Beskhmelnitsyna, Michael V. Korokin, Tatyana V. Avtina, Lev N. Sernov, Anton N. Tishin, Darya A. Kostina
TRPA1 is an ankyrin receptor of TRP family. It is mostly expressed in the smalldiameter nociceptors with cell bodies located in the dorsal roots, as well as in trigeminal, nodose ...

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