Research result: pharmacology and clinical pharmacology

Issue №1 (6) 2017
EXPERIMENTAL PHARMACOLOGY

DERMATOPROTECTIVE ACTIVITY OF A COMBINATION OF ENOXIFOL WITH REXOD IN A REDUCED FORM THE BLOOD CIRCULATION IN THE SKIN IN DIABETES MELLITUS AND HYPERCHOLESTERINEMIA

Valeria V. Seletskaya, Pavel A. Galenko-Yaroshevskii

Experiments in rats showed that the 9-diethylaminoethyl-2-(3,4-dioxyphenyl)-imidazo-[1,2-a]-benzimidazole dihydrobromide with the provisional name of enoxifol (0.94 – 15 mg/kg), rexod (recombinant human superoxide dismutase; 0.002 mg/kg) and especially their combination in ...

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N-ALKENYLIMIDAZOLE METAL COMPLEX DERIVATIVES AS EFFECTIVE AGENTS FOR THE HYPOXIC CONDITIONS

Svetlana A. Shakhmardanova, Pavel A. Galenko-Yaroshevskii

The relevance. The therapy of hypoxemic conditions by the substances, which are differing because of their key role in the vital processes of metabolism and also their high pharmacological activity, ...

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STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART

Kesarev Oleg Georgievich, Danilenko Lyudmila Mikhailovna, Pokrovskii Mikhail Vladimirovich, Timokhina Alena Sergeevna, Khavanskii Anatolii Vyacheslavovich

In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function ...

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PHARMACOLOGICAL EFFICACY OF AN INHIBITOR OF ARGINASE-2 KUD975 WITH L-NAME-INDUCED ENDOTHELIAL DYSFUNCTION

Konstantin V. Kudryavtsev, Mikhail V. Korokin, Oleg S. Gudyrev

The study of endotelio- and cardioprotective activity of finished dosage forms - tablets, film-coated, containing 10 mg of phenolic nature KUD-975, was shown a statistically significant decrease in blood ...

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THE DEVELOPMENT OF HYPERTENSIVE NEURORETINOPATHY MODEL ON WISTAR RATS

Anna A. Peresypkina, Alexander A. Dolzhikov, Viktoriya O. Gubareva, Elena A. Levkova, Anna S. Shabelnikova

A model of hypertensive neuroretinopathy was developed on Wistar line rats with administration of non-selective NO-synthase blocker N-nitro-L-arginine methyl ester (L-NAME) in a dose 12.5 mg/kg within 28 days on ...

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CLINICAL PHARMACOLOGY

APPROACHES TO ANTIBIOTIC THERAPY IN PATIENTS WITH CALCULOUS PYELONEPHRITIS, UNDERGOING IN-PATIENT TREATMENT IN THE DEPARTMENT OF UROLOGY

Nikolaj G. Filippenko, Tatyana N. Malorodova, Tatyana G. Pokrovskaya, Sergey A. Batishchev, Tatyana I. Kulchenkova, Valeriya P. Lihodedova, Janna S. Urojevskaya

Urolithiasis is one of the most common urologic diseases and it is found more than 3% of the population of Russia, which is complicated by calculous pyelonephritis from 43-81% up ...

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CLINICAL EFFICACY OF A BETABLOCKERS THERAPY IN PATIENTS WITH CHRONIC HEART FAILURE ON THE BACKGROUND OF POSTINFARCTION CARDIOSCLEROSIS

Olga A. Osipova, Vladimir F. Kulikovskii, Kseniya G. Plaksina, Evgenii A. Shabanov, Elena V. Gosteva

Despite the fact that betablockers (BBs) are one of the main groups of therapy of patients with acute myocardial infarction (AMI), the comparative effectiveness of various BBs in patients with ...

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EFFICACY AND SAFETY OF PHARMACOLOGICAL TREATMENT OF THE WITH CLINICALLY APPARENT BACTERIURIA AND ASYMPTOMATIC BACTERIURIA IN THE PREGNANT WOMEN

Dmitry G. Likhikh, Galina A. Lazareva

The article explores the problem of urinary tract infection in pregnant women. It presents the statistical analysis of the frequency of different forms of urinary tract infection during pregnancy. ...

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VETERINARY PHARMACOLOGY

EFFICIENCY OF CAROTINE-CHLOROPHYLLIC COMPLEXES USE IN A- HYPOVITAMINOSIS OF POULTRY

Ljudmila V. Reznichenko  , Inessa N. Jakovleva, Aeksej A. Reznichenko, Nina A. Denisova, Nadezhda G. Savushkina, Tatyana S. Shevchenko, Elena A. Shentseva, Sergey V. Zherebnenko

As is known, poultry is very sensitive to the lack of vitamins in the case of stress or diseases, reducing food intake and reducing intestinal absorption of vitamins. Deficiency of ...

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THE INFLUENCE OF THE CONCENTRATION OF MONTMORILLONITE CONTAINING SORBENT AND PH OF THE CULTURE MEDIUM ON THE ANTIBIOTIC SENSITIVITY OF ESCHERICHIA COLI, AS WELL AS THE EFFECT OF GROUND ON GROWTH OF ESCHERICHIA

Vladimir D. Bukhanov, Aleksandr I. Vezentsev, Olga V. Filippova, Sergei V. Nadezhdin, Olga N. Pankova, Tatyana I. Firsova, Mariya O. Mikhailyukova, Anton N. Tishin

Diseases of a digestive tract in frequency and mass manifestation of young farm animals represent one of challenges for modern veterinary medicine. Giving chelators specific properties by immobilization on ...

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PHARMACOLOGYCAL REVIEWS

SEARCH OF NEW PHARMACEUTICALS ON THE BASIS OF DARBEPOETIN IN THE TREATMENT OF ISCHEMIC STROKE (REVIEW OF LITERATURE)

 , Konstantin M. Reznikov , Narine S. Gorbunova, Pavel D. Kolesnichenko , Alexey V. Tverskoy, Dariya A. Kostina, Dariya A. Bashkatova , Vladislava A. Nikitina , &nbsp

The article contains the analysis of medical and biological publications from the global database created by the National Centre for Biology Information (NCBI), an intramural biotechnological division of the US ...

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NUCLEAR FACTOR KAPPA B AS A POTENTIAL TARGET FOR PHARMACOLOGICAL CORRECTION ENDOTHELIUM-ASSOCIATED PATHOLOGY

Vera A. Ragulina, Daria A. Kostina, Anton P. Dovgan, Yuri E. Burda, Sergey V. Nadezhdin

The nuclear factor kappa B (NF-κB) is one of transcription factors. A high interest in studying the biological role of the signal system and its contribution to the development ...

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