Research result: pharmacology and clinical pharmacology

Issue №1 (6) 2017
EXPERIMENTAL PHARMACOLOGY

DERMATOPROTECTIVE ACTIVITY OF A COMBINATION OF ENOXIFOL WITH REXOD IN A REDUCED FORM THE BLOOD CIRCULATION IN THE SKIN IN DIABETES MELLITUS AND HYPERCHOLESTERINEMIA

Experiments in rats showed that the 9-diethylaminoethyl-2-(3,4-dioxyphenyl)-imidazo-[1,2-a]-benzimidazole dihydrobromide with the provisional name of enoxifol (0.94 – 15 mg/kg), rexod (recombinant human superoxide dismutase; 0.002 mg/kg) and especially their combination in ...

N-ALKENYLIMIDAZOLE METAL COMPLEX DERIVATIVES AS EFFECTIVE AGENTS FOR THE HYPOXIC CONDITIONS

The relevance. The therapy of hypoxemic conditions by the substances, which are differing because of their key role in the vital processes of metabolism and also their high pharmacological activity, ...

STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART

In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function ...

PHARMACOLOGICAL EFFICACY OF AN INHIBITOR OF ARGINASE-2 KUD975 WITH L-NAME-INDUCED ENDOTHELIAL DYSFUNCTION

The study of endotelio- and cardioprotective activity of finished dosage forms - tablets, film-coated, containing 10 mg of phenolic nature KUD-975, was shown a statistically significant decrease in blood ...

THE DEVELOPMENT OF HYPERTENSIVE NEURORETINOPATHY MODEL ON WISTAR RATS

A model of hypertensive neuroretinopathy was developed on Wistar line rats with administration of non-selective NO-synthase blocker N-nitro-L-arginine methyl ester (L-NAME) in a dose 12.5 mg/kg within 28 days on ...

CLINICAL PHARMACOLOGY

CLINICAL EFFICACY OF A BETABLOCKERS THERAPY IN PATIENTS WITH CHRONIC HEART FAILURE ON THE BACKGROUND OF POSTINFARCTION CARDIOSCLEROSIS

Despite the fact that betablockers (BBs) are one of the main groups of therapy of patients with acute myocardial infarction (AMI), the comparative effectiveness of various BBs in patients with ...

EFFICACY AND SAFETY OF PHARMACOLOGICAL TREATMENT OF THE WITH CLINICALLY APPARENT BACTERIURIA AND ASYMPTOMATIC BACTERIURIA IN THE PREGNANT WOMEN

The article explores the problem of urinary tract infection in pregnant women. It presents the statistical analysis of the frequency of different forms of urinary tract infection during pregnancy. ...

VETERINARY PHARMACOLOGY
PHARMACOLOGYCAL REVIEWS

SEARCH OF NEW PHARMACEUTICALS ON THE BASIS OF DARBEPOETIN IN THE TREATMENT OF ISCHEMIC STROKE (REVIEW OF LITERATURE)

The article contains the analysis of medical and biological publications from the global database created by the National Centre for Biology Information (NCBI), an intramural biotechnological division of the US ...

NUCLEAR FACTOR KAPPA B AS A POTENTIAL TARGET FOR PHARMACOLOGICAL CORRECTION ENDOTHELIUM-ASSOCIATED PATHOLOGY

The nuclear factor kappa B (NF-κB) is one of transcription factors. A high interest in studying the biological role of the signal system and its contribution to the development ...