Research result: pharmacology and clinical pharmacology

Issue №2 (3) 2016
EXPERIMENTAL PHARMACOLOGY

EXPERIMENTAL JUSTIFICATION OF NEW WAY OF PHARMACOLOGICAL CORRECTION FOR CONTACT FROSTBITE USING DSLET OPIOID PEPTIDE AND SEROTONIN ADIPINATE TO ENHANCE SURGYCAL TREATMENT

Alexander L. Chigunadze, Elena B. Artyushkova, Vladimir N. Mishustin, Galina N. Goryainova, Ekaterina V. Artyushkova
The severity of complications and a large percentage of disability related to the occurrence cold injury lead to medical, social and economic problems. Considering the contact of cold injury as ...

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PHARMACOKINETIC STUDIES DERIVED INDOLE SS-68 WITH ANTIARRHYTHMIC AND ANTIANGINAL PROPERTIES

Pavel A. Galenko-Yaroshevsky, Alexander L. Kulikov  , Dmitrij V. Vinakov, Tatyana V. Avtina,  Konstantin F. Suzdalev,  Mihail V. Pokrovskii
A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spec-trometric detector (HPLC-MS/MS). Conducted pharmacokinetic studies SS-68 in ...

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PHARMACOLOGICAL EFFICIENCY OF STATINS AND L-NORVALIN AT AN ENDOTOXIN-INDUCED ENDOTHELIAL DYSFUNCTION

Inna L. Ivlitskaya, Mihail V. Korokin, Aleksey L. Loktionov

In the animals with endotoxin-induced endothelial dysfunction there were imbalance of contractile response of vessels wall observes when carrying out functional tests, increase of coefficient of endothelial dysfunction, decrease in ...

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METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF ADEMETIONINE AND TAURINE

Taisia A. Khadieva,  Anton P. Dovgan,  Tatyana G. Pokrovskaya

Abstract. In the experiment, was made a simulation of endothelial dysfunction in male rats of Wistar-line byintraperitoneal administration of L-NAME at a dose of 25 mg/kg/day for 7 days. Deficiency ...

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MELATONIN ATTENUATES THE STRESS-INDUCED DISORDERS IN PARODONTIUM AND LIVER

Yuri D. Lyashev, Vadim S. Serikov

The results of investigation illustrate the lipid peroxidation activation in different tissues under the stress influence. The obtained results convince the different resistance of animals to stress. The decrease of ...

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EXPERIMENTAL SUBSTANTIATION EFFICIENCY OF APPLICATION OF THE AMARANTH SEEDS OIL AT COMPLICATIONS INVOKED BY ISONIAZID

Ekaterina N. Muzalevskaya

In an experimental research found that amaranth seeds press oil in dose of 600 mg/kg of the Isoniazid intoxication (in dose of 542 mg/kg during 6 days) prevents ...

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CORRECTION OF ISCHEMIC DAMAGE TO THE RETINA ON APPLICATION OF PHARMACOLOGICAL PRECONDITIONING OF RECOMBINANT ERYTHROPOIETIN

Shabelnikova A.S.

To study the protective properties of pharmacological preconditioning with recombinant erythropoietin suberitro stimulating dose of 50 IU / kg in the retina of the eye, was the model ...

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CLINICAL PHARMACOLOGY

DIABETIC FOOT SYNDROME: IMPORTANCE OF MICROBIOLOGICAL MONITORING AND ANTIMICROBIAL PENETRATION OF CHEMOTHERAPEUTIC AGENTS INTO THE SOFT TISSUE LOWER LIMB IN DETERMINING THE TREATMENT

Tatyana N. Malorodova  , Tatyana G. Pokrovskaya, Elena E. Каzаkоvа, Janna S. Urojevskaya

Foot infections are a common and serious problem in persons with diabetes. Persistent ulcers in patients with diabetic foot syndrome in 85% of cases lead to amputation because ...

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PHARMACOLOGICAL MANAGEMENT OF IMMUNE AND OXIDATIVE DISTURBANCES IN PATIENTS WITH ENCEPHALOPATHY ON THE BACKGROUND OF HYPERTENSION

Anastasia A. Shulginova, Elena Y. Voronina, Nataliya A. Bistrova

Prior to treatment in patients with discirculatory encephalopathy stage II affected by hypertensive disease set at the system level elevation of proinflammatory and regulatory cytokines, stable metabolites of ...

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VETERINARY PHARMACOLOGY

INFLUENCE OF THE ENTEROSORBENT ON QUALITY OF EGGS

Vladimir D. Buhanov, Alexander I. Vesentsev, Lyudmila I. Naumenko, Pavel V. Sokolovsky, Olga N. Pankova

In this article research the influence of natural montmorillonite containing sorbent used as a mineral supplement in animal feed in an amount of 30 g per 1 kg ...

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THE INFLUENCE OF ELECTROLYTES OF THE IONS AND THE INHIBITOR ON THE ACTIVITY OF TOTAL ATPASE OF ERYTHROCYTES OF BROILER CHICKENS

Irina P. Mosyagina, Vladimir V. Mosyagin

The total ATPase activity of erythrocytes of broiler chickens depends on the concentration of ions Na+ and K+. The ATPase activity at 76.5% due to magnesium ions, 96.5% ...

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A METHOD FOR PRODUCTION OF PHYTOMINERALSORBENT, PHYSICAL AND CHEMICAL PROPERTIES OF IT, EFFECT ON THE LIVING SYSTEMS AND THE QUALITY OF THE LIVESTOCK INDUSTRY PRODUCTS.

Inessa N. Yakovleva, Andrey A. Shaposhnikov  , Alexandr I. Vezenczev, Victoria U. Kovaleva  , Ludmila R. Zakirova, Tatyana S. Shevchenko, Elena A. Shentseva

Numerous experimental studies have shown that the sorption-active substances can clarify the reservoir, soils, drinking municipal water from unwanted impurities with a sufficient degree of effectiveness; eliminate the potentially toxic ...

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