Research result: pharmacology and clinical pharmacology

Issue №2 (7) 2017
EXPERIMENTAL PHARMACOLOGY

PLEYOTROPIC ANTIAGGREGANT EFFECTS OF AN INNOVATIVE ANTIARRHYTHMIC OF CLASS III SS-68, AN INDOLE DERIVATIVE

Background: A new indole derivative with the lab code-number SS-68 demonstrates a significant antiarrhythmic (anti-fibrillation) activity associated with the predominant influence on potassium and calcium conductivity of cardiomyocytes plasmalemmas. ...

PRECLINICAL STUDY OF THE EFFICACY AND SAFETY OF WOUND HEALING GEL CONTAINING CHITOSAN, TAURINE AND ALLANTOIN

Introduction: The paper deals with the problem of wound healing, which is considered to remain one of the most pressing challenges of the modern medicine, despite a large variety ...

EXPERIMENTAL RATIONALE FOR THE USE OF FLUIDS WITH DIFFERENT REDOX POTENTIAL AS A BASIS FOR INFUSION THERAPY

Introduction: The hypothesis is that a change in the redox potential (Red-Ox) of infusion solutions can increase their pharmacological efficacy. Objectives: To study the parameters of redox potential (ORP ...

PHARMACOLOGICAL EFFECTS OF THE SYNTHETIC ANALOGUE OF ANTIMICROBIAL PEPTIDE OF INDOLICIDIN 21 ON THE REGENERATION OF THERMAL WOUNDS IN THE EXPERIMENT

Introduction: Burn injuries in developed countries are among the most spread injuries of peacetime. The growth of resistance of microorganisms to existing antibiotics makes it necessary to develop some ...

TEST SYSTEM FOR EVALUATION OF THE INFLUENCE OF THE BIOLOGICAL ACTIVITY OF SUBSTANCES ON THE SIGNAL SYSTEM OF NF-ΚB: FOCUS ON THE DERIVATIVES OF 3-HYDROXYPYRIDINE

Introduction: The nuclear factor kappa B is one of the most promising targets for the development of innovative medicines in the development of modern pharmacology and the formation of ...

EVALUATION OF CARDIOPROTECTIVE EFFECTS OF THE INCRITIN MIMETICS EXENATIDE AND VILDAGLIPTIN IN THE EXPERIMENT

Introduction: The results of experimental and clinical trials make it clear that incretin mimetics possess pleiotropic effects and demonstrate the value in terms of assessment of their potential opportunities ...

CLINICAL PHARMACOLOGY

PHARMACOLOGICAL CORRECTION OF FETOPLACENTAL INSUFFICIENCY WITH FETAL GROWTH RETARDATION SYNDROME

Introduction: fetoplacental insufficiency (FPI) is an important problem of obstetrics. This pathological condition leads to the development of fetal growth retardation syndrome (FGRS). Any standard treatment regimens cannot exist ...

THE METHODOLOGY OF ASSESSING THE EFFECTIVENESS OF THE THERAPY

Objectives: To substantiate the methodology for assessing the effectiveness of drug therapy, based on the effect of therapy not only on the target organ or function, but also on ...

NEW DOSAGE FORM OF L-ARGININE BASED ON ITS COMPLEX WITH CELLULOSE ACETATE SULFATE AND ACTIVATED CARBON

Introduction: The oral route of L-arginine intake, despite its great comfort, is less effective in comparison with infusions. The development of new pharmaceutical forms for oral preparation is of ...

PHARMACOLOGYCAL REVIEWS

NANOPARTICLES AS AGENTS FOR TARGETED DELIVERY IN THE TREATMENT OF VASCULAR PATHOLOGIES

Inflammation in the pathogenesis of cardiovascular diseases. Inflammation is the cornerstone of CVD. Systemic inflammation can lead to activation of the endothelium characterized by increased expression of endothelial adhesion ...

PHYSICO-CHEMICAL PROPERTIES OF MONTMORILLONITE CLAYS AND THEIR APPLICATION IN CLINICAL PRACTICE (REVIEW)

The review is devoted to the medical application of montmorillonite clay minerals. Properties and mechanisms of action of enterosorbents. The properties of the enterosorbents include an absorption capacity and ...