Research result: pharmacology and clinical pharmacology

Issue №3 (4) 2016
EXPERIMENTAL PHARMACOLOGY

ANTICHOLINERGIC ACTIVITY AND PHARMACOKINETIC PARAMETERS OF AGENT SS-68 WITH PROPERTIES OF CLASS III ANTIARRHYTHMIC DRUGS

Bogus Saida K., Kulikov Alexandr L., Vinakov Dmitry V., Suzdalev Konstantin P., Galenko-Yaroshevskii Pavel A
It was shown that the indole derivate SS-68 (50 and 250 µg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is ...

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NEW APPROACHES OF MORFOFUNKTIONAL PHARMACOLOGICAL CORRECTION OF VIOLATIONS OF CARDIOVASCULAR SYSTEM IN EXPERIMENTAL PREECLAMPSIA

Gureev Vladimir V
Experimental Modeling ADMA-like preeclampsia administration to rats was performed by N-nitro-L-arginine methyl ester, from 14 to 20 days of pregnancy. The animals were observed increase in blood pressure, proteinuria, impaired ...

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CARDIOVASCULAR EFFECTS OF AN ARGINASE II SELECTIVE INHIBITOR

Yakushev Vladimir Ivanovich,  , Mikhail Vladimirovich Pokrovskii
For the first time in vitro experiments there were studied the inhibitory activity and safety of potential molecules arginase II selective inhibitors from the group of norleucine derivatives. Also first ...

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CLINICAL PHARMACOLOGY

THE CHOICE OF ANTIMICROBIAL THERAPY AMONG PHYSICIANS IN THE TREATMENT OF GESTATIONAL PYELONEPHRITIS

Chuhareva Natalya Alexandrovna,  , Bontsevich Roman Alexandrovich,  , Shchurovskaya Kristina Vladimirovna,  , ​Denisova Darya Sergeevna
From 1 to 10% of the physiological pregnancy complicated by acute pyelonephritis. The purpose work- analyze the choice of antimicrobial therapy among physicians in the treatment of gestational pyelonephritis. Materials ...

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COMPREHENSIVE EVALUATION OF COMBINED PHARMACOTHERAPY OF CARDIAC PATHOLOGY CONSIDERING EXOGENOUS AND PHARMACOGENETIC FACTORS

Kornilov Arsen Alexandrovich,  , Luneva Julia Vladimirovna,  , Povetkin Sergej Vladimirovich
The study assessed changes in hemodynamic and biochemical parameters, vascular age and 5-year cardiovascular risk on the background of complex pharmacotherapy in patients with stable angina I-III functional class (FC), ...

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АТP AS THE MARKER OF POWER EXCHANGE CONDITION AT THE EXPERIMENTAL ISCHEMIA OF THE MYOCARDIUM DUE TO METABOLIC DRUGS INTRODUCTION

Kukes Vladimir Grigorevich,  , Gorbach Tatyana Victorovna,  , Romashchenko Olesya Victorovna,  , Rumbesht Vadim Valerevich
For the purpose of definition of an adequate marker of a power exchange condition at the experimental ischemia of the myocardium due introduction of metabolic drugs, the experimental research on ...

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VETERINARY PHARMACOLOGY

THE ANTIBACTERIAL PROPERTIES OF MODIFIED BENTONITE DEPOSIT TAM BO

Bui Quang Cu,  , Nguen Hoai Chao,  , Vesentsev Alexander Ivanovich,  , Bukhanov Vladimir Dmitrievich,  , Sokolovsky Pavel Viktorovich,  , Mihaylyukova Mariya Olegovna
In this article, the antibacterial properties enriched bentonite Tam Bo deposit, Lam Dong Province (Vietnam) modified in various ways: alkali - by processing enriched bentonite LiOH solution at a temperature ...

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THE ETIOLOGICAL STRUCTURE OF MASS DISEASES WITH YOUNG GASTRO AND RESPIRATORY SYNDROME

Zuev Nikolaj Petrovich,  , Bukhanov Vladimir Dmitrievich,  , Vesentsev Alexander Ivanovich,  , Sokolovsky Pavel Viktorovich,  , Khmyrov Aleksey Vladimirovich,  , Zueva E. N.,  , Salashnaya E. А.,  ,  , Mihaylyukova Mariya Olegovna, &nbsp
The study of the etiology and pathogenesis of diseases gastrointestinal and respiratory tract, the development of effective methods of these treatment and prevention are of great economic importance in ensuring ...

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PHARMACOLOGYCAL REVIEWS

THE POSSIBILITY OF ADMINISTRATION OF GLUTAMATE RECEPTORS ANTAGONISTS IN THE TREATMENT OF PARKINSON'S DISEASE

Avdeeva Natalya Viktorovna,  , Nikitina Vladislava Aleksandrovna,  , Kochkarova Indira Sultanovna,  , Litvinova Anna Sergeevna
Parkinson's disease is the slow-progressing chronic neurodegenerative disease. It caused by the progressive destruction and death of neurons that produce the neurotransmitter dopamine, primarily in the substantia nigra and also ...

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METABOLIC CARDIOPROTECTION: NEW CONCEPTS IN IMPLEMENTATION OF CARDIOPROTECTIVE EFFECTS OF MELDONIUM

Danilenko Lyudmila Mikhaelovna,  , Klochkova Galina Nikolaevna,  , Kizilova Irina Vladimirovna,  , Korokin Michael Viktorovich
Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects. ...

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THYMOSIN Β4 AS BASIS FOR CREATION OF A REPARATION PREPARATION OF NEW GENERATION

Martynov Mikhail Alekseevich,  , Martynova Olga Viktorovna,  , Shkileva Irina Yurevna,  , Tokarev Ivan Aleksandrovich,  , Dovgan Anton Pavlovich
In article is narrated about Thymosin β4. Its structure, a number of strategically important properties and opportunities is described. The list of researches and achievements over the past few years ...

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PARADIGM OF MODERN PHARMACOLOGY: DEVELOPMENT AND CURRENT APPROACHES

Reznikov K.M.
The article focuses on the current approach to understanding pharmaceutical products’ effect. It describes a paradigm shift in views on pharmaceutical action in correlation to the processes occurring under pathology. ...

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