Research result: pharmacology and clinical pharmacology

Issue №4 (5) 2016
EXPERIMENTAL PHARMACOLOGY

PHARMACOKINETIC STUDIES OF NEW ANTIPARKINSONIAN DRUG RAPITALAM

Avdeeva Natalia Viktorovna, Kulikov Alexandr Leonidovich, Pokrovskii Mikhail Vladimirovich, Avtina Tatyana Valerevna
Parkinson's disease is the most common neurodegenerative disorder after Alzheimer's disease. The aim of this study was to investigate the pharmacokinetic parameters of the mGluR4 receptor blocker Rapitalam on rabbits. ...

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ASSESSMENT OF THE DNA DAMAGE LEVEL IN PERIPHERAL BLOOD LEUKOCYTES OF MICE TREATED ORALLY WITH RAPITALAM IN ACUTE AND THERAPEUTIC DOSES

Natalia V. Avdeeva, Dmitrii V. Kravchenko, Mikhail V. Korokin
Rapitalam is a drug that is a modulator of the mglur4 receptor - a kind of metabotropic glutamate receptors. Into BelSU Clinical and Preclinical Studies Centre there was performed experimental ...

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EVALUATION EFFICIENCY OF MODERN ANTIDEPRESSANTS BY MEANS OF QUANTATIVE PHARMACO-EEG

Oksana M. Kudelina, Dmitry P. Khloponin, Yury S. Maklyakov, Vladimir G. Zaika, Elena V. Gantsgorn
Introduction. Currently, topicality the problem of diagnosis and treatment of depressive disorders (DD) in medical practice is not in doubt. The drugs of choice in the treatment of this affective ...

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EXPERIMENTAL INVESTIGATION OF PHARMACOKINETIC PROPERTIES AND THE ACCUMULATION OF ZINC WHEN ADMINISTRATED NANOFORM OF ZINC HYDROXIDE IN A COMPARATIVE ASPECT WITH ZINC SULFATE

Sergei L. Larin, Anna R. Zvyagintseva, Anatoliy A. Habarov, Elena V. Budko
Pharmacological correction of the imbalance of zinc is important for a comprehensive treatment of microelementoses human. Existing zinc preparations limited in their application, so as active ingredients used oxide and ...

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CORRECTION OF RETINAL ANGIOPATHY OF HYPERTENSIVE TYPE BY MINOXIDIL, SILDENAFIL IN EXPERIMENT

Anna A. Peresypkina, Viktoriya O. Gubareva, Elena A. Levkova , Anna S. Shabelnikova
For the study of retinoprotective properties of pharmacological agents a model of retinal angiopathy of hypertensive type was created against the background of N-nitro-L-arginine methyl ester (L-NAME) administration in a ...

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PHARMACOLOGICAL EVALUATION POLYSACCHARIDE COMPLEX FLOWERS TANSY

Elena N. Yakusheva, Ekaterina E. Engalycheva, Igor A. Sychev , Aleksey V. Shcul’kin
From flowers tansy extracted polysaccharide complex. Installed its qualitative and quantitative composition, have developed a technique standardizing the content of reducing sugars. By thin layer chromatography and high pressure liquid ...

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CLINICAL PHARMACOLOGY

PHARMACOTHERAPY EXACERBATIONS OF CHRONIC INFLAMMATORY CONDITIONS OF FEMALE GENITAL SPHERE USING TO GEPON AND LONGIDAZA

Svetlana N. Abramova, Galina A. Lazareva
Researches of the last years showed that changes of local immunity at inflammatory diseases of appendages at women, to be exact a condition of a secondary immunodeficiency at the local ...

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THE ANALYSIS OF PREFERENCES OF OBSTETRICIANS-GYNECOLOGISTS AND THERAPISTS OF BELGOROD REGION IN HEARTBURN AND CONSTIPATION TREATMENT IN PREGNANT WOMEN IN COMPARISON WITH ALL-RUSSIAN DATA.

N.A. Chuhareva, R.A. Bontsevich, R.M. Esayan, K.V. Shchurovskaya, A.V. Lysenko
Summary. One of the most frequent accompanying pathologies during pregnancy – digestive tract diseases. The work purpose - to analyse the choice of medicinal therapy among doctors at heartburn and ...

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COMPLEX THERAPY OF CHRONIC PANCREATITIS COMPLICATED BY ANXIO-DEPRESSIVE DISORDERS IN RAILROAD WORKERS

Svetlana Sergeevna Lyubavskaya, Yury Nikolayevich Chernov, Galina Alexandrovna Batishcheva, Igor Borisovich Ushakov, Nataliya Yuryevna Goncharova
Psychic disorders in patients, who suffer from chronic somatic diseases for a long time, can be grouped into one category called psychosomatic pathology. Co-morbid - psychosomatic - disorders are considered ...

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VETERINARY PHARMACOLOGY

CHELATE COMPLEXES OF MALIC OR CITRIC ACIDS WITH IRON, MANGANESE AND ZINC AS A BIOLOGICALLY ACTIVE SUPPLEMENT FOR BROILER CHICKEN DIET

Natalya A. Kochetkova, Elena G. Yakovleva, Andrey A. Shaposhnikov, Tatyana S. Shevchenko, Ludmila R. Zakirova
The aim of the present study was to define the effects of the various doses of biologically active supplement, which was consisted of iron, manganese, zinc malates and citrates, on ...

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INFLUENCE OF L- LYSINE SULFATE ON CONTAINING OF VITAMINS AND MINERALS IN THE BODY OF BROILER CHICKENS

Andrey A. Shaposhnikov, Inessa N. Yakovleva, Irina V. Nedopekina, Ulyana A. Krut, Lydmila R. Zakirova
Experimental researches have shownthatthe L-lysine sulfate (the product of microbiological synthesis) has a positive effect on metabolism of vitamins A, E, C in the liver and minerals calcium and phosphorus ...

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PHARMACOLOGYCAL REVIEWS

DEVELOPMENT PERSPECTIVES OF NEW GENERATION MEDICATIONS BASED ON THE REDOX SYSTEM REGULATORS

Svetlana A. Shahmardanova, Olga N. Gulevskaya, Pavel A. Galenko-Yaroshevsky, Pavel D. Kolesnichenko
This survey paper describes the necessity of the development of new medications influencing the body redox-potential. It supports the most pressing branch of pharmacology, which coincides with logically relevant attempts ...

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