USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION
For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environment. In animal experiments it was shown that granulirovannye the form of a combined preparation in dosages of 30 mg/kg, 70 mg/kg and 200 mg/kg exhibits a pronounced anti-hypertensive, endothelioprotecive and cardioprotective activity in a dosage of 200 mg/kg.
Figure 1. Adsorption isotherms of L-arginine and L-arginine -Na-SAC on activated carbons at T = 298 K.
1 – complex L-arginine - Na-SAC on AUT-MI; 1’– L-arginine on AUT-MI; 2–complex L-arginine - Na-SAC on ОU-А; 2’– L-arginine on ОU-А; 3 – complex L-arginine - Na-SAC on TH-90G; 3’ – L-arginine on TH-90G
Maximum Gibbs adsorption value, specific surface area and pore structure characteristics of the applied activated carbons
Figure 2. Surface tension isotherms of aqueous solutions at T = 298 K.
1 –Na-CAS; 2 – L-arginine; 3 – complex L-arginine-Na-CAS.
The effect of new dosage form of L-arginine on hemodynamics values and EDC in modeling of L-NAME-induced endothelium dysfunction (M±m n=10)
The effect of new dosage form of L-arginine on the left ventricle of rats’ heart contractility (M±mn=10)
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Shakhno E.A., Savitskaya T.A., Pokrovskaya T.G., Yakushev V.I., Pokrovskii M.V., Grinshpan D.D. Use of L-arginine immobilised on activated carbon for pharmacological correction of endothelial disfunction. Research result: pharmacology and clinical pharmacology. 2016. Vol. 2, №1 (2): 30-35.