This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.
Indicators of endothelial dysfunction coefficient, Total NOx and homocysteine concentration in rat blood plasma upon modeling and correction of homocysteine-induced endothelial dysfunction by arginase II selective inhibitor (substance code ZB49-0010C) (n=10, М±m).
Effect of arginase II selective inhibitor (substances under the code ZB49-0010C) on functional contractility indices of left ventricular myocardium during stress tests upon modeling of hyperhomocysteinemia-induced ED (M±m, n=10).
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Yakushev V.I., Filippenko N.G., Kizilova I.V., Korokin M.V., Beskhmelnitsyna E.A., Litvinova A.S. Studying dosedependent endothelio- and cardioprotective activity of selective arginase II inhibitor in hyperhomocysteineinduced endothelial dysfunction. Research result: pharmacology and clinical pharmacology. 2016. Vol. 2, №1 (2): 42-45.