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PHARMACOLOGICAL EFFICIENCY OF STATINS AND L-NORVALIN AT AN ENDOTOXIN-INDUCED ENDOTHELIAL DYSFUNCTION

In the animals with endotoxin-induced endothelial dysfunction there were imbalance of contractile response of vessels wall observes when carrying out functional tests, increase of coefficient of endothelial dysfunction, decrease in contractility of a myocardium, activation processes of peroxidation of lipids and decreased activity of antioxidant systems, level of stable metabolites of nitrogen oxide. On extent of decrease in corrective effects on indicators of functional activity of a vessel wall, contractility of a myocardium, oxidatic indicators and level of stable metabolites of nitrogen oxide are studied preparations settle down in the following sequence: L-norvalin and rozuvastatin (coefficient of endothelial dysfunction – 1,2±0,1) → L-norvalin and simvastatin (coefficient of endothelial dysfunction – 1,5±0,1) → rozuvastatin (coefficient of endothelial dysfunction – 1,6±0,1) → L-norvalin (coefficient of endothelial dysfunction – 1,7±0,2) → symvastatin (coefficient of endothelial dysfunction – 2,0±0,2).

Figures

Table 1. Results of carrying out functional vascular assays on animals with EIED (M±m; n=10)

Table 2. Change of functional activity of a myocardium of animals with EIED receiving statinsor L-norvalin(M±m; n=10)

Table 3. Results of carrying out functional vascular tests on animals with EIED  and its correction by means of a rozuvastatin, a symvastatin and L-norvalin(M±m; n=10)

Figure 1. Change of oxidatic indicators and level of stable metabolites of nitrogen oxide at rats with EIED against application of statins and L-norvalin

Table 4. Results of carrying out functional vascular tests on animals with EIED and its correction by combinations of  rozuvastatin,  simvastatin and L-norvalin (M±m; n=10)

Table 5. Correction of functional activity of  myocardium at animals with EIED, combinations  of statins and L-norvalin(M±m; n=10)

Figure 2.  Change of oxidatic indicators and level of stable metabolites of nitrogen oxide on rats with EIED against the combined application of statins and LL-norvalin.

DOI: 10.18413/2313-8971-2016-2-2-25-35
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