Research Results in Pharmacology
Volume 6, Issue №1, 2020
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EXPERIMENTAL PHARMACOLOGY
Antiplatelet activity of new derivatives of benzimidazole containing sterically hindered phenolic group in their structure
Introduction: Cardiovascular diseases are currently the leading cause of global disability and mortality. According to the centers for disease control and prevention, the average life expectancy of a person would ...
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Clinical and Experimental Rationale for Antioxidant Therapy of Chronic Bacterial Prostatitis
Introduction: Literature data prove the important role of oxidative stress in the pathogenesis of Chronic Bacterial Prostatitis (CBP) and its recurrence, which reduces the effectiveness of standard etiotropic therapy of ...
Effect of Сomplex Therapy with Cortexin on the State of the Body's Regulatory Systems
in Patients with Rosacea
Introduction: For treating patients with rosacea, it is important to study the effectiveness of drugs with both neuromodulating activity and immunomodulatory properties. The aim of the study is to examine ...
Correction of Morphofunctional Disorders of the Cardiovascular System with Asialized Erythropoietin and Arginase II Selective Inhibitors KUD 974 and KUD 259 in Experimental Preeclampsia
Introduction: Preeclampsia remains one of the most common causes of maternal and perinatal mortality worldwide. A significant role in the pathogenesis of this pathology is assigned to placental ischemia and ...
Study of Protective Properties of Butyrylcholinesterase in Acute Anticholinesterase Poisoning on BChE-KO and BALB/c Mice
Introduction: The article presents the results of studying the protective properties of recombinant human butyrylcholinesterase (rhBChE) in a model of acute anticholinesterase poisoning in mice knocked out for the BChE ...
Role of Arginase 2 as a Potential Pharmacological Target for the Creation of New Drugs to Correct Cardiovascular Diseases
Introduction: The review provides relevant information about arginase 2, the role of this enzyme in the formation of endothelial dysfunction and, as a consequence, the development of cardiovascular diseases. History ...
Biological Activity of Mesenchymal Stem Cells Secretome as a Basis for Cell-Free Therapeutic Approach
Mesenchymal stem (stromal) cells (MSCs) are self-renewing, cultured adult stem cells which secrete a complex set of multiple soluble biologically active molecules such as chemokines, and cytokines, cell adhesion molecules, ...
Role of orexin peptide systeminemotional overeatinginduced by brain reward stimulation in fed rats
Introduction: The purpose of this work was to prove that the reaction of food self-deprivation in “fed up” rats is a suitable model for studying the emotional overeating in the ...
Molecular Docking Studies of N-substituted 4-methoxy-6-oxo-1-aryl-pyridazine-3-carboxamide Derivatives as Potential Modulators of Glutamate Receptors
Introduction: The virtual target-oriented screening is a necessary stage of modern drug-design. In the present study, the affinity of pyridazine derivatives for the most promising antiparkinsonian biotargets – I-III groups ...
Pharmacotherapy and Other Aspects of Senior Medical Students’ Knowledge in Community-Acquired Pneumonia: the Final Results of the KNOCAP II Project
Introduction: Community-acquired pneumonia (CAP) remains an extensive medical and social problem. It is the most common human disease and one of the leading causes of death from infectious diseases. Increasing ...
