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Research Results in Pharmacology

Volume 4, Issue №2, 2018
UNCATEGORIZED

ENDOTHELOTROPIC ACTIVITY OF 4-HYDROXY-3,5-DI-TRET-BUTYLCINNAMIC ACID IN THE CONDITIONS OF EXPERIMENTAL CEREBRAL ISCHEMIA

Introduction: The aim of the study was to evaluate the endothelioprotective activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in conditions of experimental cerebral ischemia. Materials and methods: The brain ischemia was ...

IMIDAZOLINE RECEPTORS AGONISTS: POSSIBLE MECHANISMS OF ENDOTHELIOPROTECTION

Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In this review, the historical, physiological, pathophysiological aspects concerning imidazoline receptor ...

2-AMINOAETHANESULFONIC ACID COMPOUNDS POSSESS PROTECTIVE PROPERTY IN REPERFUSION-INDUCED HEART JNJURY

The study aim was to explore pharmacological effects of 2-aminoaethansulfonic acid compounds in reperfusion-induced heart injury. Materials and methods. The study was performed on rats and dogs of both ...

ASSESSMENT OF PHARMACOLOGICAL ACTIVITY AND BIOAVAILABILITY OF THE NEW DERIVATIVE 1,3,4-THIADIAZOLE

Introduction: Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid. Materials and Methods: In animal experiments, acute toxicity, pharmacological activity and bioavailability of acexazolamide were evaluated. Anti-inflammatory ...

ANALYSIS OF CHANGES IN PHARMACOTHERAPY OF STABLE ANGINA OVER THE FIVE-YEAR PERIOD AT SPECIALIZED OUT-PATIENT LEVEL OF MEDICAL CARE (PHARMACOEPIDEMIOLOGICAL STUDY)

Introduction: Ischemic heart disease (IHD) remains the leading cause of death both in Europe and in Russia. The most common form of IHD is stable angina. There is compelling evidence that ...

PRINCIPLES OF PHARMACOLOGICAL CORRECTION OF PULMONARY ARTERIAL HYPERTENSION

Definition and classification: Pulmonary hypertension (PH) is a group of life-threatening progressive diseases of various genesis, characterized by a progressive increase in arterial pressure (AP) in the pulmonary artery ...

EXPERIMENTAL AND CLINICAL STUDY OF THE EFFICACY OF MEDICINES CONTAINING OMEGA-3 AND 6 POLYUNSATURATED FATTY ACIDS, IN THE TREATMENT OF INFLAMMATORY SKIN DISEASES

Introduction: Over the recent years, the attention of scientists regarding the search for alternative means of treatment, including local therapy, of inflammatory skin diseases, has been focused in recent ...

PHARMACOLOGICAL CORRECTION OF INTRARENAL HEMODYNAMIC DISORDERS IN ACUTE KIDNEY INJURY (PART 2)

Introduction: Treatment of acute kidney injury (AKI) is a complex current problem. Mortality in this pathology is over 50%. One of the areas of correction therapy in AKI patients is the ...

DISORDERS OF THE IMMUNE STATUS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA; DIFFERENTIATED PHARMACOLOGICAL CORRECTION

Introduction: Chronic cerebral ischemia (CCI) accounts for 60-75% of all cerebrovascular diseases in Russia and around the world. The problem: the issues concerning the role of immunity in the pathogenesis ...

PHARMACOLOGICAL SCREENING OF SUBSTANCES WITH CARDIOPROTECTIVE EFFECT IN THE GROUP OF 3-OXYPYRIDINE DERIVATIVES

Introduction: The search for new compounds with antihypoxic and cardioprotective effects among 3-oxypyridine derivatives is promising. Research objectives: To study the anti-hypoxic and cardioprotective effects of 3-oxypyridine derivatives. ...

2-PHENYL-1-(3-PYRROLIDIN-1-IL-PROPYL)-1 H-INDOLE HYDROCHLORIDE (SS-68): ANTIARRHYTHMIC AND CARDIOPROTECTIVE ACTIVITY AND ITS MOLECULAR MECHANISMS OF ACTION (PART I)

Introduction. The problem of heart rhythm disturbances is one of the most urgent topics of modern cardiology. According to the currently available concepts, 1,2- and 1,3-disubstituted aminoindole derivatives, which compound ...