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Research Results in Pharmacology

Volume 6, Issue №2, 2020 PDF
EXPERIMENTAL PHARMACOLOGY

On the way from SARS-CoV-sensitive mice to murine COVID-19 model

The coronavirus disease 2019 (COVID-19) is a master killer which appeared suddenly and which has already claimed more than 200,000 human lives. In this situation, laboratories are in urgent need ...

Novel mGluR4 agonist Rapitalam ameliorates motor dysfunction in mice with tau-associated neurodegeneration
 

Introduction: Tau protein is classically involved in the pathogenesis of a neurodegenerative processes, such as Parkinson’s disease. This study was aimed at testing the novel mGluR4 selective agonist using it ...

A Novel View of the Problem of Osteoarthritis in Experimental Rat Model
 

Introduction: The article presents the results of the functional tests to improve the assessment of MIA-induced osteoarthritis development and the effectiveness of NSAID therapy. Materials and Methods: In the study, ...

Evaluation of the Effectiveness of Pharmacotherapy for Brain and Heart Diseases by Monitoring the Effects of Drugs
 

Introduction: The study aims at analyzing the possibility of using a method of monitoring the action of drugs in real-time to assess the effectiveness of pharmacotherapy for brain and heart ...

The Effect of Early and Late Pharmacological Correction with GABA derivatives of Psychoemotional State of Offspring of Rats with Experimental Preeclampsia
 

Introduction: Preeclampsia is a serious complication of pregnancy, which increases the risk of anxiety disorders and depression in children at different stages of ontogenesis. Materials and Methods: The psychoemotional state ...

Preclinical Study of Innovative Peptides Mimicking the Space Structure of the α-helix B of Erythropoietin
 

Introduction: The aim of this study was to examine the effectiveness of innovative peptides obtained by addition of polypeptide motifs with antiaggregation activity (Arg-Gly-Asp, Lys-Gly-Asp and Pro-Gly-Pro) to a peptide ...
CLINICAL PHARMACOLOGY

Medication Adherence in Patients with Stable Coronary Artery Disease in Primary Care
 

Introduction: Lack of research targeting non-adherence to cardiovascular medications in Russia prevents from developing effective interventions to improve adherence. The aim was to study medication adherence in patients with stable ...
PHARMACOLOGYCAL REVIEWS

Amphotericin B from Antifungal to Antiviral Therapy: Promising Modern Therapeutic Branch
 

Introduction: Amphotericin B (AmB) which belongs to the polyene group has a wide spectrum in vitro and in vivo antimicrobial activity against fungi and parasites, but resistance to ...

Modern Approaches to the Treatment of Chronic Polypous Rhinosinusitis
 

Introduction: Today, chronic polypous rhinosinusitis (CPR) occupies a special place among otolaryngological diseases, the incidence rate of which increases every year. To date, the main causes of chronic polypous rhinosinusitis ...