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Research Results in Pharmacology

Volume 7, Issue №2, 2021
Uncategorized

Features of the immune status in patients with chronic and complicated pyodermas:
choice of a therapeutic correction method

Introduction:  To compare the features of the immune status in patients with chronic and complicated pyoderma in the course of complex pharmacotherapy using immunomodulators based on transfer factors and ...

In vivo study of pharmacokinetic parameters of a new combination drug based on citicoline and memantine

Introduction: Cognitive impairment (dementia) is one of the most common pathologies with increasing numbers of patients. Most often they are the symptoms of Alzheimer’s disease and vascular brain ...

Study to elucidate the pharmacological activity of retinalamin in a rat model of ischemic retinopathy
 

Introduction: Over the past few years, the incidence of retinal ischemic disorders has been increasing, due to a rising prevalence of such socially burdensome diseases as diabetes and hypertension, ...

Activity of ROS-induced processes in the combined preconditioning with amtizol before and after cerebral ischemia in rats
 

Introduction: The dose-dependent effect of reactive oxygen species (ROS) in tissues in preconditioning (PreC) and oxidative stress, as well as NO-synthase participation in mitochondrial ROS production determined the study ...

Migraine pharmacology and brain ischemia
 

Introduction: The aim of this review article was to analyze in details the mechanism of drugs’ effects in the treatment and prevention of a migraine attack, as well as ...

Distribution, excretion and metabolic pathways of a single parenteral administration of kappa-opioid receptor agonist RU-1205
 

Introduction: The purpose was to study the pharmacokinetic properties of RU-1205 with the previously identified kappa-agonistic and analgesic effects after parenteral administration. Materials and Methods: Pharmacokinetic parameters of ...

Proteins of allogeneic hepatocytes and pharmacological preparations for the correction of immunometabolic disorders in experimental liver pathology
 

Introduction: The relationship of numerous metabolic shifts, disorders of hepatocytes functional activity resulting from hypoxia and toxic liver damage with the function of the immune system has not been ...