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Research Results in Pharmacology

Volume 3, Issue №4, 2017
EDITORIAL

OSVALD SHMIDEBERG – IS A GENIUS, THE «FATHER» OF EXPERIMENTAL PHARMACOLOGY

Biography. Oswald Schmiedeberg (1838-1921) was a son of a bailiff and a maid of honour, the eldest of the six children in the family. He was born and educated ...
EXPERIMENTAL PHARMACOLOGY

STUDY OF ANALEPTIC ACTIVITY OF TETRAHYDROPYRIDO [2,1-B] [1,3,5] TIADIAZINE DERIVATIVES

Abstract Introduction: Our goal is to conduct an investigation of the analeptic activity of the tetrahydropyrido [2,1-b] [1,3,5] thiadiazine derivative group. Materials and methods: Biological studies were ...

ANTI-INFLAMMATORY AND ANALGETIC PROPERTIES OF THE INDOOR SS-68

The experiments with rats show that when administered intravenously (5 mg/kg) and intragastrically (5, 10, 15 and 20 mg/kg), SS-68 compound exerts an anti-inflammatory effect (AIE) on models of ...

PHARMACOTHERAPEUTIC STRATEGIES FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH USE OF STATINES IN SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE

Objectives: The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are not fully developed. Goal: Determination of statins’ new pharmacological ...

LIGAND OF PERIPHERAL IMIDAZOLINE RECEPTORS BASED ON AMIDES OF HETEROCYCLIC ACIDS C7070: EFFECT ON ISHEMIZED TISSUES

Introduction: In this regard, the study of pleiotropic hepatoprotective properties of the agonist of peripheral imidazoline receptors C7070 seems interesting from an applied point of view. Materials and ...

STUDY OF PHARMACOLOGICAL ACTIVITY OF NIGELLA DAMASCENA FIXED OIL IN EXPERIMENT

Introduction: Literature data, rich chemical macro-microelement composition set the stage for experimental pharmacological study of adaptogene and lipid protective activity of Nigella damascena essential oil. Objectives: study of ...

INTERACTION BETWEENSOME ANTIBIOTICS AND ANTIOXIDANTS

Introduction: The bactericidal action of many antibacterial agents has a common mechanism associated with the generation of hydroxyl radicals and the activation of oxidative stress. This is confirmed by ...

CORRECTION OF RETINAL ANGIOPATHY OF HYPERTENSIVE TYPE BY DIMETHYLAMINOETHANOL DERIVATIVE 19-16 IN EXPERIMENT

Introduction: 63% of hypertensive patients have evidence of hypertensive angiopathy. Increase of effectiveness of drug therapy of retinal angiopathy of hypertensive type is an important task of pharmacology. <p ...

STUDY OF PHARMACOLOGICAL ACTIVITY IN SUBLIMATED CULTURE LIQUID OF ALLOGENIC, XENOGENEIC HEPATOCYTES AND FIBROBLASTS FOR THE CORRECTION OF LIVER DAMAGES IN CARBON TETRACHLORIDE INTOXICATION

Introduction: At the present time many clinical and experimental studies are devoted to the correction of hepatocytes and liver functional abnormalities with the use of cellular technologies. Materials ...

EFFECT OF PHARMACOLOGICAL PRECONDITIONING WITH INCRETINOMIMETICS EXENATIDE AND VILDAGLIPTIN ON THE SURVIVAL OF ISCHEMIC TISSUES

Introduction: Currently, much attention is paid to the pleiotropic effects of entretenimiento. Purposes: Study of the protective effect exenatide and valdiation with pharmacological correction of ischemic myocardial damage, ...
CLINICAL PHARMACOLOGY

OPTIMIZATION IMMUNEPHARMACOTHERAPY OF PYOINFLAMMATORY DISEASES

Introduction: The results of clinical investigation of several pyoinflammatory diseases are presented. Objectives: On clinical data of various models of pyoinflammatory diseases - deep pyodermia (UCP), chronic salpingooforitis ...