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EXPERIMENTAL PHARMACOLOGY

STUDY OF ANALEPTIC ACTIVITY OF TETRAHYDROPYRIDO [2,1-B] [1,3,5] TIADIAZINE DERIVATIVES

Volume 3, Issue №4, 2017
Abstract Introduction: Our goal is to conduct an investigation of the analeptic activity of the tetrahydropyrido [2,1-b] [1,3,5] thiadiazine derivative group. Materials and methods: Biological studies were ...

PHARMACOTHERAPEUTIC STRATEGIES FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH USE OF STATINES IN SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE

Volume 3, Issue №4, 2017
Objectives: The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are not fully developed. Goal: Determination of statins’ new pharmacological ...

INTERACTION BETWEENSOME ANTIBIOTICS AND ANTIOXIDANTS

Volume 3, Issue №4, 2017
Introduction: The bactericidal action of many antibacterial agents has a common mechanism associated with the generation of hydroxyl radicals and the activation of oxidative stress. This is confirmed by ...

ANTI-INFLAMMATORY AND ANALGETIC PROPERTIES OF THE INDOOR SS-68

Volume 3, Issue №4, 2017
The experiments with rats show that when administered intravenously (5 mg/kg) and intragastrically (5, 10, 15 and 20 mg/kg), SS-68 compound exerts an anti-inflammatory effect (AIE) on models of ...

EFFECT OF PHARMACOLOGICAL PRECONDITIONING WITH INCRETINOMIMETICS EXENATIDE AND VILDAGLIPTIN ON THE SURVIVAL OF ISCHEMIC TISSUES

Volume 3, Issue №4, 2017
Introduction: Currently, much attention is paid to the pleiotropic effects of entretenimiento. Purposes: Study of the protective effect exenatide and valdiation with pharmacological correction of ischemic myocardial damage, ...

STUDY OF PHARMACOLOGICAL ACTIVITY OF NIGELLA DAMASCENA FIXED OIL IN EXPERIMENT

Volume 3, Issue №4, 2017
Introduction: Literature data, rich chemical macro-microelement composition set the stage for experimental pharmacological study of adaptogene and lipid protective activity of Nigella damascena essential oil. Objectives: study of ...

LIGAND OF PERIPHERAL IMIDAZOLINE RECEPTORS BASED ON AMIDES OF HETEROCYCLIC ACIDS C7070: EFFECT ON ISHEMIZED TISSUES

Volume 3, Issue №4, 2017
Introduction: In this regard, the study of pleiotropic hepatoprotective properties of the agonist of peripheral imidazoline receptors C7070 seems interesting from an applied point of view. Materials and ...

CORRECTION OF RETINAL ANGIOPATHY OF HYPERTENSIVE TYPE BY DIMETHYLAMINOETHANOL DERIVATIVE 19-16 IN EXPERIMENT

Volume 3, Issue №4, 2017
Introduction: 63% of hypertensive patients have evidence of hypertensive angiopathy. Increase of effectiveness of drug therapy of retinal angiopathy of hypertensive type is an important task of pharmacology. <p ...

TADALAFIL AS AN AGENT OF PHARMACOLOGICAL PRECONDITIONING IN ISCHEMIC - REPERFUSION BRAIN INJURY

Volume 3, Issue №3, 2017
Introduction: Ischemic stroke or cerebral infarction is the main pathology among severe forms of vascular lesions of the brain. One of the more effective non-medicamental methods of treatment is ...

RESEARCH OF WOUND HEALING EFFECT OF PHYTOMINERALSORBENT ON THE BASIS OF MONTMORILLONITE

Volume 3, Issue №3, 2017
Introduction: The results of preclinical investigation of the wound healing effect of phytomineralsorbent (PMS) based on montmorillonite are presented. Objectives: Study of the possibilities of pharmacological correction of ...

POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070

Volume 3, Issue №3, 2017
Introduction: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonistС7070. Materials and methods: The experiment was carried out on ...

PRECLINICAL STUDY OF PHARMACOLOGICAL ACTIVITY OF ENTEROSORBENTE ON THE BASIS OF MONTMORILLONITE

Volume 3, Issue №3, 2017
Introduction: At present, enterosorbents based on mineral raw materials are in high demand among the population. However, there are no enterosorbents on the Russian pharmaceutical market on the basis ...

EVALUATION OF CARDIOPROTECTIVE EFFECTS OF THE INCRITIN MIMETICS EXENATIDE AND VILDAGLIPTIN IN THE EXPERIMENT

Volume 3, Issue №2, 2017
Introduction: The results of experimental and clinical trials make it clear that incretin mimetics possess pleiotropic effects and demonstrate the value in terms of assessment of their potential opportunities ...

PLEYOTROPIC ANTIAGGREGANT EFFECTS OF AN INNOVATIVE ANTIARRHYTHMIC OF CLASS III SS-68, AN INDOLE DERIVATIVE

Volume 3, Issue №2, 2017
Background: A new indole derivative with the lab code-number SS-68 demonstrates a significant antiarrhythmic (anti-fibrillation) activity associated with the predominant influence on potassium and calcium conductivity of cardiomyocytes plasmalemmas. ...

PHARMACOLOGICAL EFFECTS OF THE SYNTHETIC ANALOGUE OF ANTIMICROBIAL PEPTIDE OF INDOLICIDIN 21 ON THE REGENERATION OF THERMAL WOUNDS IN THE EXPERIMENT

Volume 3, Issue №2, 2017
Introduction: Burn injuries in developed countries are among the most spread injuries of peacetime. The growth of resistance of microorganisms to existing antibiotics makes it necessary to develop some ...

EXPERIMENTAL RATIONALE FOR THE USE OF FLUIDS WITH DIFFERENT REDOX POTENTIAL AS A BASIS FOR INFUSION THERAPY

Volume 3, Issue №2, 2017
Introduction: The hypothesis is that a change in the redox potential (Red-Ox) of infusion solutions can increase their pharmacological efficacy. Objectives: To study the parameters of redox potential (ORP ...
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