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CLINICAL PHARMACOLOGY

OPTIMIZATION IMMUNEPHARMACOTHERAPY OF PYOINFLAMMATORY DISEASES

Volume 3, Issue №4, 2017
Introduction: The results of clinical investigation of several pyoinflammatory diseases are presented. Objectives: On clinical data of various models of pyoinflammatory diseases - deep pyodermia (UCP), chronic salpingooforitis ...

PHARMACOLOGICAL CORRECTION OF INTERCEPT HEMODYNAMICS IN ACUTE KIDNEY DAMAGE (PART 1)

Volume 3, Issue №3, 2017
Introduction: Development of vasoconstriction of kidney arterioles and reduction of renal blood flow is one of the main mechanism of acute kidney injury (AKI) formation. Methods for evaluation of ...

NEW APPROACHES TO PREVENTION OF NSAID-GASTROPATHY

Volume 3, Issue №3, 2017
Introduction: At present, the issue of gastric mucosal damage, induced by the use of non-steroidal anti-inflammatory drugs, remains unresolved. Objectives: The development of new methods of prevention of ...

INTERLEUKIN-6 IS A POTENTIAL TARGET FOR A CORRECTION OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH LOW-GRADE SYSTEMIC INFLAMMATION

Volume 3, Issue №3, 2017
Introduction: One of pathogenetic links of development of endothelial dysfunction, as an early marker of cardiovascular disease and comorbidity, is a low-grade systemic inflammation. In this regard, correction of ...

ADAPTIVE DESIGN IN CLINICAL DEVELOPMENT OF NEXT-IN-CLASS DRUGS

Volume 3, Issue №3, 2017
Introduction: The next-in-class drugs are the original drugs that by chemical structure and mode of action similar to their predecessors of the same pharmacological group. The clinical development of ...

COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE

Volume 3, Issue №3, 2017
Introduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences. Objectives: The aim ...

PHARMACOLOGICAL CORRECTION OF FETOPLACENTAL INSUFFICIENCY WITH FETAL GROWTH RETARDATION SYNDROME

Volume 3, Issue №2, 2017
Introduction: fetoplacental insufficiency (FPI) is an important problem of obstetrics. This pathological condition leads to the development of fetal growth retardation syndrome (FGRS). Any standard treatment regimens cannot exist ...

NEW DOSAGE FORM OF L-ARGININE BASED ON ITS COMPLEX WITH CELLULOSE ACETATE SULFATE AND ACTIVATED CARBON

Volume 3, Issue №2, 2017
Introduction: The oral route of L-arginine intake, despite its great comfort, is less effective in comparison with infusions. The development of new pharmaceutical forms for oral preparation is of ...

THE METHODOLOGY OF ASSESSING THE EFFECTIVENESS OF THE THERAPY

Volume 3, Issue №2, 2017
Objectives: To substantiate the methodology for assessing the effectiveness of drug therapy, based on the effect of therapy not only on the target organ or function, but also on ...

EFFICACY AND SAFETY OF PHARMACOLOGICAL TREATMENT OF THE WITH CLINICALLY APPARENT BACTERIURIA AND ASYMPTOMATIC BACTERIURIA IN THE PREGNANT WOMEN

Volume 3, Issue №1, 2017
The article explores the problem of urinary tract infection in pregnant women. It presents the statistical analysis of the frequency of different forms of urinary tract infection during pregnancy. ...

PHARMACOTHERAPY EXACERBATIONS OF CHRONIC INFLAMMATORY CONDITIONS OF FEMALE GENITAL SPHERE USING TO GEPON AND LONGIDAZA

Volume 2, Issue №4, 2016
Researches of the last years showed that changes of local immunity at inflammatory diseases of appendages at women, to be exact a condition of a secondary immunodeficiency at the local ...

COMPLEX THERAPY OF CHRONIC PANCREATITIS COMPLICATED BY ANXIO-DEPRESSIVE DISORDERS IN RAILROAD WORKERS

Volume 2, Issue №4, 2016
Psychic disorders in patients, who suffer from chronic somatic diseases for a long time, can be grouped into one category called psychosomatic pathology. Co-morbid - psychosomatic - disorders are considered ...

COMPREHENSIVE EVALUATION OF COMBINED PHARMACOTHERAPY OF CARDIAC PATHOLOGY CONSIDERING EXOGENOUS AND PHARMACOGENETIC FACTORS

Volume 2, Issue №3, 2016
The study assessed changes in hemodynamic and biochemical parameters, vascular age and 5-year cardiovascular risk on the background of complex pharmacotherapy in patients with stable angina I-III functional class (FC), ...

THE CHOICE OF ANTIMICROBIAL THERAPY AMONG PHYSICIANS IN THE TREATMENT OF GESTATIONAL PYELONEPHRITIS

Volume 2, Issue №3, 2016
From 1 to 10% of the physiological pregnancy complicated by acute pyelonephritis. The purpose work- analyze the choice of antimicrobial therapy among physicians in the treatment of gestational pyelonephritis. Materials ...

АТP AS THE MARKER OF POWER EXCHANGE CONDITION AT THE EXPERIMENTAL ISCHEMIA OF THE MYOCARDIUM DUE TO METABOLIC DRUGS INTRODUCTION

Volume 2, Issue №3, 2016
For the purpose of definition of an adequate marker of a power exchange condition at the experimental ischemia of the myocardium due introduction of metabolic drugs, the experimental research on ...
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