Research result: pharmacology and clinical pharmacology

Выпуск №1 (2) 2016
EXPERIMENTAL PHARMACOLOGY

ENDOTHELIUM AND CARDIOPROTECTIVE EFFECTS OF HMG-CO-A-REDUCTASE IN COMBINATION WITH L-ARGININE IN ENDOTHELIAL DYSFUNCTION MODELING

 , Denisyuk Tatiana Alekseevna, Lazareva Galina Anatol'evna, Provotorov Vladimir Yakovlevich, Shaposhnikov Andrey Aleksandrovich, &nbsp
Abstract. Using the combined application of L-arginine with HMG-Co-A reductase inhibitors simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of modeling of sepsis-induced disease through the introduction of strain ...

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ENDOTHELIOPROTECTIVE PROPERTY OF THE COMBINATION OF THE THIOCTIC ACID AND ROSUVASTATIN SHOWN IN THE ENDOTHELIAL DYSFUNCTION MODELS

Olga Viktorovna Molchanova, Tatyana Grigorevna Pokrovskaya, Sergej Vladimirovich Povetkin, Konstantin Mihajlovich Reznikov
During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same ...

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ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA

Vladimir Yakovlevich Provotorov, Michael Viktorovich Korokin, Mikhail Vladimirovich Pokrovskii, Sergej Vladimirovich Povetkin, Galina Anatol'evna Lazareva, Aleksandr Aleksandrovich Stepchenko, Natalya Anatol'evna Bystrova
The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg ...

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STUDY OF THE INFLUENCE OF L-NORVALINE, ROSUVASTATIN AND THEIR COMBINATION ON THE LEVEL OF MICROCIRCULATION IN BONE TISSUE IN EXPERIMENTAL OSTEOPOROSIS AND FRACTURES ON ITS BACKGROUND

Densingh Samuel Raj Rajkumar, Олег Сергеевич Гудырев, Александр Владимирович Файтельсон, Александр Александрович Степченко, Александр Анатольевич Должиков, Сергей Владимирович Поветкин
К сожалению, статья недоступна на русском языке.

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PHARMACOLOGICAL PRECONDITIONING BY RECOMBINANT ERYTHROPOIETIN AS THE POSSIBILITY OF INCREASING THE STABILITY OF TISSUE OF THE RETINA TO REPERFUSION ISCHEMIA IN EXPERIMENT

Anna Sergeevna Shabelnikova, Anna Alexandrovna Peresypkina, Viktoriya Olegovna Gubareva, Elena Aleksandrovna Levkova, Alexander Anatolievich Dolzhikov, Sergej Borisovich Nikolaev, Aleksandr Aleksandrovich Stepchenko
Ischemic injury was formed in laboratory rats by applying mechanical pressure (110 mm Hg) to the anterior eye chamber for 30 minutes. The experiment revealed that the recombinant erythropoietin (50 ...

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USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION

Екатерина Александровна Шахно, Татьяна Александровна Савицкая, Татьяна Григорьевна Покровская, Владимир Иванович Якушев, Михаил Владимирович Покровский, Дмитрий Давидович Гриншпан
К сожалению, статья недоступна на русском языке.

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PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED OXIDE DEFICIENCY WITH DERIVATIVES OF 3-(2,2,2- TRIMETHYLHYDRAZINIUM) PROPIONATE

Sophia Yakovlevna Skachilova, Oleg Georgievich Kesarev, Lyudmila Mikhaelovna Danilenko, Natalya Anatol'evna Bystrova, Alexander Anatolievich Dolzhikov, Sergej Borisovich Nikolaev
This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have shown that 3-(2,2,2-trimethylhydrazinium) propionate and its derivatives reduced the expression ...

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STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION

Vladimir Ivanovich Yakushev, Nikolaj Grigor'evic Filippenko, Irina Vladimirovna Kizilova, Michael Viktorovich Korokin, Evgeniya Alexandrovna Beskhmelnitsyna, Anna Sergeevna Litvinova
This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The ...

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CLINICAL PHARMACOLOGY

ANALYSIS OF DYNAMICS OF ANTIBIOTIC RESISTANCE OF PATHOGENS IN PATIENTS WITH DIABETIC FOOT SYNDROME UNDERGOING IN-PATIENT TREATMENT

Galina Aleksandrovna Batishcheva, Tatyana Nikolaevna Malorodova, Tatyana Grigorevna Pokrovskaya, Elena Evgenevna Каzаkоvа, Janna Sergeevna Urojevskaya, Nina Ivanovna Zhernakova, Ol'ga Aleksandrovna Osipova
Persistent ulcers in patients with diabetic foot syndrome in 85% of cases lead to amputation because of secondary infection and growing gangrene that significantly worsen the prognosis. In the course ...

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DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF THE NEW ANTIDIABETIC DRUG IN THE BLOOD PLASMA OF RATS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

Andrey Anatolyevich Buzov, Aleksandr Leonidovich Kulikov, Tatyana Valer'evna Avtina, Mikhail Vladimirovich Pokrovskii, Ol'ga Aleksandrovna Osipova
We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range ...

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MOLECULAR SCREENING

TEST-SYSTEM FOR ESTIMATION OF ACTIVITY OF GSK-3 INHIBITORS AS ANTIHYPOXANTS AND DIFFERENTIATION OF ENDOTHELIAL PROGENITORS IN VITRO

Youri Evgenievich Burda, Sergey Victorovich Nadezhdin, Ekaterina Vladimirovna Zubareva, Mikhail Vladimirovich Pokrovskii, Alexander Vladimirovich Faitelson, Svetlana Yourievna Burda, Maria Sergeevna Shirina
A model test-system was developed for validation in vitro of antihypoxic and endothelio-differentiating activity of newly created glycogen synthase kinase-3 inhibitors in comparison with the reference drug β4-thymosin.

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MOLECULAR SCREENING OF PROSPECTIVE CANDIDATES FOR TRPA1 ION CHANNEL SELECTIVE ANTAGONISTS

Dmitrii Vladimirovich Kravchenko, Evgeniya Alexandrovna Beskhmelnitsyna, Michael Viktorovich Korokin, Tatyana Valer'evna Avtina, Lev Nikolaevich Sernov, Anton Nikolaevich Tishin, Darya Aleksandrovna Kostina
TRPA1 is an ankyrin receptor of TRP family. It is mostly expressed in the smalldiameter nociceptors with cell bodies located in the dorsal roots, as well as in trigeminal, nodose ...

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