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POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070

Introduction: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonistС7070.

Materials and methods: The experiment was carried out on 70 rats of both sexes, divided into 7 groups (n = 10): an intact group; Pseudo-operated animals (autopsy of the abdominal wall without ligation of the liver vessels); Ischemia / reperfusion group without drug correction; Animals undergoing ischemia / liver reperfusion + Metformin (50 mg / kg); Animals undergoing ischemia / liver reperfusion + Moxonidine (1 μg / kg); Animals undergoing ischemia / liver reperfusion + C7070 (1 mg / kg). For the evaluation, the coefficients calculated from the level of hepatic transaminases (ALT, AST), as well as morphometric ratios of the area of necrosis and deep ischemia of the liver, were used for the evaluation according to the histological examination.

Results and discussion: The indicated agonists of peripheral imidazoline I2receptors (C7070) significantly reducesischemically-reperfusion injury of the liver, in comparison with the preparations of moxonidine and metformine. Indirect sign of imidazoline activating mechanism of C7070 is decreasing of the hepatoprotective effect of C7070 by the preliminary administration of imidazoline receptor blocker BU-224. The coefficients for ALT / AST for C7070, moxonidine and metformin were 72.8 / 62.13, respectively; 44.99 / 34.20 and 36.88 / 21.02. The coefficients of the morphological hepatoprotective activity of the preparations were: С7070 – 82.61, moxonidine – 72.33, metformin – 38.96.

Conclusions: The imidazoline receptor agonists significantly and significantly reduce the functional and morphological manifestations of liver ischemia / reperfusion.

Иллюстрации

Table 1

The influence of agonists of imidazoline receptors at the level of ALT and AST in modeling of ischemia/reperfusion of the liver (M±m, n=10)

Notice: * –p>0.05 incomparingwithintactgroup, ** –p>0.05 incomparingwithpseudo-operatedgroup,1 – p>0.05 incomparingwithischemia/reperfusiongroup.

Table 2

The influence of agonists of imidazoline receptors in the area of ischemic damage to the liver and area of the zone of necrosis of liver tissue by modeling of ischemia/reperfusion of the liver (M±m, n=10)

Notice: * – p>0.05 incomparingwithischemia/reperfusiongroup.

ALT (exp) – ALT level in blood of experimental animals,

ALT (ctrl) – ALT level in blood of control (I/R) animals.

AST (exp) – AST level in blood of experimental animals,

AST (ctrl) – AST level in blood of control (I/R) animals.

Table 3

Hepatoprotective activity С7070, moxonidine and Metformin in modeling of ischemia/reperfusion of the liver according biochemical research (M±m; n=10)

Notice: * – p>0.05 incomparingwithmoxonidine and metforminegroups.

Мi (exp) – mean area of ischemic injury of liver in experimental animals;

Мn (exp) – mean necrosis area in liver of experimental animals;

Мi (ctrl) –mean area of ischemic injury of liver in control (I/R) animals;

Мn (ctrl) – mean necrosis area in liver of experimental animals.

Table 4

Hepatoprotective activity С7070, moxonidine and Metformin when modelirovanii ischemia/reperfusion of the liver according moramerica research (M±m; n=10)

Notice: * - р<0.05 in comparing with. 2 и 3.

DOI: 10.18413/2313-8971-2017-3-3-3-8
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