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COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE

Introduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences.

Objectives: The aim of this study was to find ways to increase the efficacy and safety of treating patients with acne by complex pharmacological correction of its manifestations.

Methods: The study included 110 people (32 men and 78 women) aged from 17 to 35 years, divided into 5 equal groups (according to the type of therapy) and observed for 6 months. All the patients underwent a comprehensive examination, including calculation of the dermatological index of acne (DIA), psychometric tests  as well as an immunological study.

Results and discussion: Monotherapy with combined topical agents leads to a decrease in DIA (48.75%) and the length of remission for more than 6 months in 46.4% of observations. Phabomotisol decreased DIA count and improved psychometric parameters. Ionized liquid (IL) led to an increase in CD4 + lymphocytes (14.48%) and immunoregulatory index (40.88%), decreased in the number of CD8 + lymphocytes (17.92%). The most effective combination was phabomotisol and IL (negative redox potential): DIA decreased (74.36%), remission of more than 1 year was observed in 22.7% patients.

Conclusion: Effectiveness therapy with phabomotizol was shown. Effectiveness of IL in the complex treatment of acne in the medium-severe course of the disease is estimated for the first time. Presence of immunotropic properties of IL was established. Possibility of achieving long-term remission without the use of antibiotic therapy was demonstrated.

Иллюстрации

Fig. 1. Dynamics of changes in DIA (scores) in each patient with standard therapy

Fig. 2. Duration of remission in patients with acne (standard therapy, %)

Table 1. Dynamics of psychometric indicators (М±m, score, %) standart treatment (n=22)

Note: * − р<0.05 compared with the indicators before treatment.

Fig. 3. Dynamics of changes in DIA (scores) in each patient in the appointment of combined topical therapy

Fig. 4. The duration of remission in patients with acne in the appointment of combined topical therapy, %

Table 2. Dynamics of psychometric indicators (М±m, score, %) of patients with the appointment of combined topical therapy (n=22)

Note: * − р<0.05 compared with the indicators before treatment

Fig. 5. Dynamics of changes in DIA (scores) in each patient treated with phabomotisol

Fig. 6. Duration of remission in acne patients treated with phabomotisol, %

Table 3. Dynamics of psychometric indicators (М±m, score, %) of acne patients treated with fabomotisol (n=22)

Note: * − р<0.05 compared with the indicators before treatment.

Fig. 7. Dynamics of changes in DIA (scores) in each patient patients when included in the treatment of ionized fluids

Fig. 8. Duration of remission of patients with acne when included in the treatment of ionized liquids, %

Table 4. Dynamics of psychometric indicators (М±m, score, %) in patients with the inclusion of ionized fluids (n=22)

Note: * − р<0.05 compared with the indicators before treatment.

Fig. 9. Dynamics of changes in DIA (scores) in each patient treated with phabomotisol and ionized fluids

Fig. 10. The duration of remission when included in the treatment of acne fabomotisol and ionized fluids, %

Table 5. Dynamics of changes in immunological indices (М±m, UD, %) of patients treated with phabomotisol and  ionized fluids (n=22)

Note: * − р<0.05 compared with the indicators before treatment.

Table 6. Dynamics of psychometric indicators (М±m, scores, %) in patients treated with phabomotisol and  ionized fluids (n=22)

Note: * − р<0.05 compared with the indicators before treatment.

Table 7.  Spearman correlation coefficients for anxiety and DIA

Note: * – Correlation is significant at the level of 0.05 (two-sided)

DOI: 10.18413/2313-8971-2017-3-3-97-109
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