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A comparative evaluation of the efficacy of dimethylaminoethanol derivative 7–16, C7070 and picamilon in correction of experimental hypertensive neuroretinopathy

Introduction. The efficacy of dimethylaminoethanol (DMAE) derivative 7–16, substance C7070 in comparison with picamylon in hypertensive neuroretinopathy model in white laboratory rats was evaluated.

Materials and methods. For measuring the blood pressure, a system of noninvasive blood pressure measurement in small animals NIBP200 was used. Ophthalmoscopy was performed by using Bx a Neitz ophthalmoscope (Japan) and Osher MaxField 78D lens, OI-78M model. Electroretinography (ERG) was recorded in response to a single stimulation. Biopotentials were presented graphically on the screen with the help of BIOPAC SYSTEMS MP-150 with ACQKNOWLEDGE 4.2 software (USA). To assess a degree of a functional retinal disorder, the b/a coefficient was used.

Results and discussion. The most pronounced protective effect on the model of hypertensive neuroretinopathy is demonstrated by C7070, which is expressed in the notable approximation to the normal eye fundus image and reaching the target values of the b/a coefficient. In the group with correction by DMAE derivative 7–16, a protective effect is observed, which exceeds picamilon, which is expressed in the elimination of soft and solid exudates, vein and venule plethora, vascular tortuosity, arterial spasm, Salus-Gunn I symptom, hemorrhages; the b/a increases significantly by 26% compared to the group without correction (p < 0.05).

Conclusion. The eye fundus image and functional state of the retina are completely restored when correcting experimental hypertensive neuroretinopathy with C7070 in a dose of 50 mg/kg to laboratory rats and partially restored when correcting with DMAE derivative 7–16 in a dose of 25 mg/kg, which in both cases exceeds the protective effect of the reference drug picamilon on the model of hypertensive neuroretinopathy.

Иллюстрации

Figure 1. The location of electrodes during ERG in a laboratory rat.

Figure 2. An example of an ophthalmoscopic picture in Wistar rats with correction of hypertensive neuroretinopathy by DMAE derivative 7–16 (A), C7070 (B).

Figure 3. The eye fundus of the rat with correction of hypertensive neuroretinopathy by picamilon.

Figure 4. Electroretinograms of Wistar rats. A control group B with simulated hypertensive neuroretinopathy.

Figure 5.

Electroretinograms of Wistar rats: A: correction of hypertensive neuroretinopathy by DMAE derivative 7–16, 25 mg/kg. B: correction of hypertensive neuroretinopathy by picamilon, 30 mg/kg. C: correction of hypertensive neuroretinopathy by C7070, 50 mg/kg.

DOI: https://doi.org/10.3897/rrpharmacology.4.29388
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