12+

ENDOTHELIUM AND CARDIOPROTECTIVE EFFECTS OF HMG-CO-A-REDUCTASE IN COMBINATION WITH L-ARGININE IN ENDOTHELIAL DYSFUNCTION MODELING

Abstract. Using the combined application of L-arginine with HMG-Co-A reductase inhibitors simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of modeling of sepsis-induced disease through the introduction of strain 603 Staphylococcus aureus shows endotelio- and cardioprotective effects, manifesting itself in preventing the proliferation of endothelial dysfunction coefficient (CED), adrenoreactivity, maintenance of myocardial reserve and the normalization of biochemical markers values (Total NO, eNOS expression, C-reactive protein, IL-6, TNF). In this case, the combined therapy was so effective that the values obtained thereunder did not differ from those obtained from control animals.

Иллюстрации

 Table 1. Influence of combined use of L-arginine with an HMG-CoA reductase inhibitor simvastatin, atorvastatin, rosuvastatin  and nanoparticulated rosuvastatin on the dynamics of hemodynamic parameters in animals with endotoxin-induced  endothelial dysfunction (M ± m, n = 10)

 Table 2.  Influence of combined use of L-arginine with an HMG-CoA reductase inhibitor simvastatin, atorvastatin, rosuvastatin  and nanoparticulated rosuvastatin on the dynamics of contractility parameters during exercise testing in animals with   endotoxin-induced endothelial dysfunction (EIED) (M ± m, n = 10)

 Table 3. Influence of combined use of L-arginine with an HMG-CoA reductase inhibitor simvastatin, atorvastatin, rosuvastatin   and nanoparticulated rosuvastatin on the dynamics of biochemical markers values (Total NO, eNOS expression,   C-reactive protein, IL-6, TNF) in animals with endotoxin-induced endothelial dysfunction (EIED) (M ± m, n = 10)

DOI: 10.18413/2313-8971-2016-2-1-4-8
Количество просмотров: 2806 (смотреть статистику)
Количество скачиваний : 604
Полный текст (HTML)Полный текст (PDF)К списку статейВ раздел
  • Комментарии
  • Список литературы

Пока никто не оставил комментариев к этой публикации.
Вы можете быть первым.

Оставить комментарий: