ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA
The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studied. It was shown that the combined use of vitamin B6 and folic acid allows on the background of a significant reduction in homocysteine concentrations normalizing the endothelial dysfunction coefficient and the parameters of maximum left ventricular pressure in response to intravenous administration of adrenaline. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.
Table 1. Effect of vitamin B6 and folic acid on functional and biochemical parameters of rats in modeling the endothelial dysfunction by intraperitoneal administration of nitro-L-arginine methyl ester (L-NAME) at a dose of 25 mg/kg (M ±m, n=10).
Table 2. Effect of vitamin B6 and folic acid on homocysteine concentration in the blood serum of experimental animals (М±m, n=10).
Table 3. Effect of vitamin B6 and folic acid on the contractile parameters of the left ventricle of rats during stress testing (M±m, n=10).
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Endothelio- and cardioprotective effects of vitamin B6 and folic acid in modelling methionine-induced hyperhomocysteinemia / V.Y. Provotorov, M.V. Korokin, M.V. Pokrovskii, S.V. Povetkin, G.A. Lazareva, A.A. Stepchenko, N.A. Bystrova //Research result: pharmacology and clinical pharmacology. – 2016. – V.2, №1(2). – P. 16-19.