12+

PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED OXIDE DEFICIENCY WITH DERIVATIVES OF 3-(2,2,2- TRIMETHYLHYDRAZINIUM) PROPIONATE

This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have shown that 3-(2,2,2-trimethylhydrazinium) propionate and its derivatives reduced the expression of NOdeficient endothelial dysfunction induced by intraperitoneal administration of N-nitro L-arginine methyl ester (L-NAME), improved the parameters of endothelium-dependent vasodilation in response to administration of acetylcholine, and reduced the coefficient of endothelial dysfunction. It was revealed that the 5-hydroxinicotinate 3-(2,2,2-trimethylhydrazinium) potassium propionate has the most pronounced endothelioprotective effect.

Иллюстрации

I – Intact; II – L-NAME; III – Mildronate® at a dose of 90 mg/kg; IV – nicotinate at a dose of 189.2 mg/kg; V – 5-bromonicotinate at a dose of 237 mg/kg; VI – 5-hydroxinicotinate at a dose of 199.1 mg/kg; VII – glycinate at a dose of 159.6 mg/kg (3-(2,2,2-trimethylhydrazinium) potassium propionate)

Figure 1 The influence of the derivatives of 3-(2,2,2-trimethylhydrazinium) potassium propionate on the systolic and diastolic blood pressure in modeling L-NAME (intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days)-induced deficiency of nitrogen oxide.

Note: *- at p = 0.05 as compared to L-NAME; **- at p = 0.05 as compared to intact animals.

I – Intact; II – L-NAME; III – Mildronate® at a dose of 90 mg/kg; IV – nicotinate at a dose of 189.2 mg/kg; V – 5-bromonicotinate at a dose of 237 mg/kg; VI – 5-hydroxinicotinate at a dose of 199.1 mg/kg; VII – glycinate at a dose of 159.6 mg/kg (3-(2,2,2-trimethylhydrazinium) potassium propionate)

Figure 2The influence of the derivatives of 3-(2,2,2-trimethylhydrazinium) potassium propionate on the endothelial dysfunction coefficient in modeling L-NAME (intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days)-induced deficiency of nitrogen oxide.

Note: *- at p = 0.05 as compared to L-NAME; **- at p = 0.05 as compared to intact animals.

DOI: 10.18413/2313-8971-2016-2-1-36-41
Количество просмотров: 2858 (смотреть статистику)
Количество скачиваний : 619
Полный текст (HTML)Полный текст (PDF)К списку статейВ раздел
  • Комментарии
  • Список литературы

Пока никто не оставил комментариев к этой публикации.
Вы можете быть первым.

Оставить комментарий: