STUDYING DOSE-DEPENDENT ENDOTHELIO- AND CARDIOPROTECTIVE ACTIVITY OF SELECTIVE ARGINASE II INHIBITOR IN HYPERHOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION
This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.
Indicators of endothelial dysfunction coefficient, Total NOx and homocysteine concentration in rat blood plasma upon modeling and correction of homocysteine-induced endothelial dysfunction by arginase II selective inhibitor (substance code ZB49-0010C) (n=10, М±m).
Effect of arginase II selective inhibitor (substances under the code ZB49-0010C) on functional contractility indices of left ventricular myocardium during stress tests upon modeling of hyperhomocysteinemia-induced ED (M±m, n=10).
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Studying dose-dependent endothelio- and cardioprotective activity of selective arginase II inhibitor in hyperhomocysteine-induced endothelial dysfunction / V.I. Yakushev, N.G. Filippenko, I.V. Kizilova, Korokin M.V., E.A. Beskhmelnitsyna, A.S. Litvinova // Research result: pharmacology and clinical pharmacology.– 2016. – V.2, №1 (2). – P. 42-45.