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PHARMACOKINETIC STUDIES DERIVED INDOLE SS-68 WITH ANTIARRHYTHMIC AND ANTIANGINAL PROPERTIES

A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spec-trometric detector (HPLC-MS/MS). Conducted pharmacokinetic studies SS-68 in the body of rabbits. Set the main pharmacokinetic parameters of the substance that allow you to optimize the future use of it’s as a potential drug in cardiology practice.

Иллюстрации

Figure 1. Mean plasma concentration-time curve of SS-68 (n = 6).

Table. 1. Mean pharmacokinetic parameters for SS-68 in the plasma rabbit (M±m; n = 6).

*Note:  AUC (0-1440) – the area under the concentration-time curve from 0 to the last sampling point (ng /ml)×min; AUMC (0-1440)  – derivative of the area under the concentration-time curve from 0 to the last sampling point (ng /ml)×min2; MRT (0-t) – mean residence time of the substance in the body, min; Kel – elimination constant, min -1; T1/2 – half-life, min; Cmax – the maximum concentration, ng/ml; Cmaxiv/AUC (0-1440) – absorption speed, min-1; tmax – time to maximum concentration of mines; С1т – systemic clearance, l / h; Vss – steady volume of distribution, l / kg; fa – absolute bioavailability,%; MAT – С1т time, min.

DOI: 10.18413/2313-8971-2016-2-2-20-24
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