Abstract. In the experiment, was made a simulation of endothelial dysfunction in male rats of Wistar-line byintraperitoneal administration of L-NAME at a dose of 25 mg/kg/day for 7 days. Deficiency of nitric oxide in result of the blockade of NO-synthase was accompanied by violation of endothelium-dependent and endothelium-undependentvasodilation assessed in pharmacological trials, which was reflected in the increase of the coefficient endotelialny dysfunction.In this case, for correction of endothelial dysfunction intraperitoneallyademetionine in the dose of 150 mg/kg and after an hour taurine at a dose of 260 mg/kg was injected the animal once a day for 7 days. The method provides effective impact of the combination of hepatoprotectorAdemetionine in the dose of 150 mg/kg/day and a sulfur-containing amino acid Taurine in the dose of 260 mg/kg/day on the functioning of the vascular endothelium, and has endotheliopathy effect on models L-NAME-induced deficiency of nitric oxide, which includesthe endothelium-dependent vasodilation and the decrease of coefficient of endothelial dysfunction.


Tabel 1. Dynamics of blood pressure parameters and heart rate in the simulation of deficiency of nitric oxide and correction of endothelial dysfunction.

Table 2. Dynamics of indicators that reflect the correction of endothelial dysfunction on the background of the introduction of L-NAME with ademetionine, taurine and their combination.

Figure 1. The values of the coefficient of endothelial dysfunction in correction with ademetionine (150 mg/kg/day), taurine (260 mg/kg/day) and their combination in comparison with the intact group and the group in modeling L-NAME (25 mg/kg intraperitoneally once daily for 7 days) induced NO deficit, *- p<0.05 compared with group L-NAME.

DOI: 10.18413/2313-8971-2016-2-2-36-40
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