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MELATONIN ATTENUATES THE STRESS-INDUCED DISORDERS IN PARODONTIUM AND LIVER

The results of investigation illustrate the lipid peroxidation activation in different tissues under the stress influence. The obtained results convince the different resistance of animals to stress. The decrease of free and bound oxyprolin content, as well as glycosaminoglycans, which are the main components of connective tissue of gingiva, after prolonged stress has been established. Stress causes the development of structural and functional disorders in the liver tissue. Melatonin is effective to inhibit the stress-induced changes in liver and parodontium. The higher efficiency of melatonin at the dose 1,0 mg/kg over 0,2 mg/kg was established. The obtained results open the prospects of the using of melatonin and its artificial analogues for pharmacological treatment of stress-induced disorders in parodontium and liver.

Ключевые слова: stress, parodontium, liver, lipid peroxidation, melatonin.

Иллюстрации

Figure 1. Stress-induced changes in parodontium of stress-nonresistant control animals: the decrease of epithelium thickness, edema, leukocyte infiltration of lamina propria. Hematoxilin&eosin. X 100.

Figure 2. Stress-induced changes in parodontium of stress-nonresistant animals treated with melatonin at the dose 1,0 mg/kg: the decrease of epithelium thickness, edema, leukocyte infiltration of lamina propria are weakly expressed. Hematoxilin&eosin. X 100.

Table 1. The influence of melatonin on the content of bound oxyprolin, glycoaminoglycans, malonic dialdehyde, acylhydroperoxides and catalase activity in gingival tissue of stress-resistant rats after chronic stress (M+-m; n=8)

Table 2. The influence of melatonin on the content of bound oxyprolin, glycoaminoglycans, malonic dialdehyde, acylhydroperoxides and catalase activity in gingival tissue of stress-nonresistant rats after chronic stress (M+-m; n=8)

 

Table 3. The influence of melatonin on morphological changes in liver tissue after prolonged decreased mobility stress (M+-m; n=8)

Figure 3. Dystrophy of hepatocytes of stress-resistant rats, exposed to prolonged decreased mobility stress. The number of dystrophic cell is low. Hematoxilin&eosin. X 140.

Figure 4. Dystrophy of hepatocytes of stress-nonresistant rats, exposed to prolonged decreased mobility stress. The number of dystrophic cell is high and heterogeneity of cytoplasm is expressed. Hematoxilin&eosin. X 140.

Table 4. Influence of melatonin on the content of lipid peroxidation metabolites and antioxidant enzymes activity in liver tissue in prolonged decreased mobility stress (M+-m; n=8)

Table 5. The influence of melatonin on the concentration of AsAT, AlAT, general proteins, albumins, glucose in the plasma of animals, exposed to 6-hour immobilization stress (M+-m; n=8)

Table 6. The influence of melatonin on the concentration of AsAT, AlAT, general proteins, albumins, glucose in the plasma of animals, exposed to prolonged decreased mobility stress (M+-m; n=8)

 

Table 7. Influence of melatonin on the content of lipid peroxidation metabolites and antioxidant enzymes activity in plasma in prolonged decreased mobility stress (M+-m; n=8)

Table 8. The influence of melatonin on the content of cholesterol, triglycerides, nonesterified fatty acids and lipoprotein of different density in plasma of rats, exposed to prolonged decreased mobility stress.

(M+-m; n=8)

Table 9. The influence of melatonin on lipid metabolism indices at the different periods after 6-hour immobilization (M+-m; n=8)

DOI: 10.18413/2313-8971-2016-2-2-41-54
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