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EXPERIMENTAL SUBSTANTIATION EFFICIENCY OF APPLICATION OF THE AMARANTH SEEDS OIL AT COMPLICATIONS INVOKED BY ISONIAZID

In an experimental research found that amaranth seeds press oil in dose of 600 mg/kg of the Isoniazid intoxication (in dose of 542 mg/kg during 6 days) prevents death of animals, reduces considerably an expressiveness of central and peripheral nervous system pathological changes, promotes normalization of digestive function and animals clinical state, lowers cytolysis syndrome manifestation degree promoting full normalization of aminotransferases activity on the 14th day. By means of biomicroscopy, using the original method of rats small intestine mesentery microvascular monitoring in an abdominal cavity, the peculiarities of microcirculatory processes disturbances invoked by high doses of Isoniazid, are revealed for the first time and the possibility of it correction via amaranth seeds oil.

Иллюстрации

Table 1. Effect of amaranth seed oil pressing to change the psychoemotional and locomotor responses in rats with isoniazid intoxication

Table 2. Change of biochemical indexes in rat blood serum under introduction of amaranth seed oil press for prophylaxis of the Isoniazid intoxication

 

Figure1A. The stomach of rats under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 3rd day of experiment.

A – intact group: stomach the normal form, the contents of the stomach uniform.

 

Figure1B. The stomach of rats under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 3rd day of experiment.

B – control group: the significant increase of stomach size connected with its overflow by undigested food masses.

Figure1C. The stomach of rats under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 3rd day of experiment.

C – essential phospholipids preparation: ventricle slightly swollen.

 

Figure1D. The stomach of rats under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 3rd day of experiment.

 D – amaranth seeds oil: stomach the normal form.

 Figure2A. Rats small intestine mesentery under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 1 hours after the Isoniazid single dosing: А – control group.

 Figure2B. Rats small intestine mesentery under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 1 hours after the Isoniazid single dosing: B – п essential phospholipids preparation.

 Figure2C. Rats small intestine mesentery under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 1 hours after the Isoniazid single dosing: C – amaranth seeds oil; arrows indicate hemorrhage.

 Figure 3A. The microcirculation bed of the small intestine mesentery under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 1 hours after the Isoniazid single dosing. Biomicroscopy, ×40: А – control group.

Figure 3B. The microcirculation bed of the small intestine mesentery under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 1 hours after the Isoniazid single dosing. Biomicroscopy, ×40:  B – essential phospholipids preparation. 

 Figure 3C. The microcirculation bed of the small intestine mesentery under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication, 1 hours after the Isoniazid single dosing. Biomicroscopy, ×40: C – amaranth seeds oil.

Table 3. Change of diameter of the mesentery microvessels in rats under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication

Table 4. Change of quantity of capillaries  and surface area of capillaries under introduction of amaranth seed oil press for prophylaxis under the conditions of the Isoniazid intoxication

 

Table 5. Change of biochemical indexes in rat blood serum under introduction of amaranth seed oil press for treatment under the conditions of the Isoniazid intoxication

Figure 4A. The histomorphological picture of liver under introduction of amaranth seed oil press for treatment under the conditions of the Isoniazid intoxication, 10th day of experiment, hematoxylin and eosine, ×400:  А – control group: fatty degeneration (1).

 Figure 4B. The histomorphological picture of liver under introduction of amaranth seed oil press for treatment under the conditions of the Isoniazid intoxication, 10th day of experiment, hematoxylin and eosine, ×400: B – essential phospholipids preparation.

 Figure 4C. The histomorphological picture of liver under introduction of amaranth seed oil press for treatment under the conditions of the Isoniazid intoxication, 10th day of experiment, hematoxylin and eosine, ×400: C – amaranth seeds oil: increase of blood filling of vessels (2).

DOI: 10.18413/2313-8971-2016-2-2-55-66
Количество просмотров: 2390 (смотреть статистику)
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