12+

CONCOMITANT USE OF STATINS AND S-(2-BORON-ETHYL)-L-CYSTEINE ARGINASE INHIBITOR TO CORRECT ENDOTOXIN-INDUCED ENDOTHELIAL DYSFUNCTION

The concomitant use of non-selective S-(2-boron-ethyl)-L-cysteine (BEC) arginase inhibitor with simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of endotoxin-induced disorder modeling by Staphylococcus aureus (strain 13407) injection under the skin – 60 billions of microbial bodies – exhibits an endothelium- and cardio-protective action which is evident as endothelial dysfunction factor (EDF) increase prevention, adrenoreactivity, maintenance of myocardial reserve, and normalization of biochemical markers (total NO, expression of eNOS, C-reactive protein, IL-6, tumor necrosis factor). However, the concomitant therapy has shown no additive action of medications.

Иллюстрации

Table 1. Influence of the concomitant use of non-selective BEC arginase inhibitor with simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on dynamics of hemodynamic parameters of animals with endotoxin-induced endothelial dysfunction (М±м, n=10).

Table 2. Influence of the concomitant use of non-selective BEC arginase inhibitor with simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on dynamics of indices of contractility in case of EKG stress tests in animals with endotoxin-induced endothelial dysfunction (М±м, n=10).

Table 3. Influence of the concomitant use of non-selective BEC arginase inhibitor with simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on value dynamics of biochemical markers (total NO, expression of eNOS, C-reactive protein, IL-6, tumor necrosis factor) of animals with endotoxin-induced endothelial dysfunction (М±м, n=10).

 

DOI: 10.18413/2500-235X-2015-1-4-4-8
Количество просмотров: 2473 (смотреть статистику)
Количество скачиваний : 665
Полный текст (HTML)Полный текст (PDF)К списку статейВ раздел
  • Комментарии
  • Список литературы

Пока никто не оставил комментариев к этой публикации.
Вы можете быть первым.

Оставить комментарий: