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HUMAN RECOMBINANT ERYTHROPOIETIN GRADIENT DOSAGE INFLUENCE ON ISCHEMIC AND REPERFUSION LIVER INJURY

We investigate influence of human recombinant erythropoietin different dosage on blood flow velocity and morphological changes in liver during ischemic and reperfusion injury. It was proved what optimal preconditioning dosage is 50 IU/kg.

Ключевые слова: ischemia, reperfusion, liver, blood flow, morphological changes.

Иллюстрации

Table 1. Human recombinant erythropoietin different dosage effect on blood flow velocity in liver microvascular vessels during ischemia and reperfusion (PU) (М±m, n=10)

Figure 1A. Ischemic liver injury: centrolobular anaemia, compact grain liver dystrophy. Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

 

Figure 1Б. Ischemic liver injury: centrolobular anaemia, compact grain liver dystrophy. Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

Figure 2A. Reperfusion liver injury: severe necrobiotic and dystrophic changes, diapedetic haemorrhage focus. Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

 

Figure 2Б. Reperfusion liver injury: severe necrobiotic and dystrophic changes, diapedetic haemorrhage focus. Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

Figure 3А. 50 IU/kg erythropoietin influence on ischemic liver injury: mild centrolobular enimia and absence of dystrophic changes. Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

Figure 3Б. 50 IU/kg erythropoietin influence on ischemic liver injury: mild centrolobular enimia and absence of dystrophic changes. Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

 

Figure 4А. IU/kg erythropoietin influence on reperfusion liver injury: venous hyperaemia, absence of hemorrhage.  Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

Figure 4Б. IU/kg erythropoietin influence on reperfusion liver injury: venous hyperaemia, absence of hemorrhage.  Hematoxylin and  eosin dye. Microphoto. А) Х 200. Б) Х400.

DOI: 10.18413/2500-235X-2015-1-4-9-14
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