THE STUDY OF OSTEOPROTECTIVE PROPERTIES OF NANOPARTICULATED FORMS OF RESVERATROL AND LOSARTAN
The study demonstrated that endothelial dysfunction of bone microvasculature and deterioration of regional blood flow in bone developed eight weeks after ovariectomy in female white Wistar rats thus raising the risk of generalized osteoporosis. Nanoparticulated forms of losartan and resveratrol possessing endothelioprotective action effectively prevented reduction of regional microcirculation in bone tissue through keeping it at the same level as intact rats had. It allowed maintaining an adequate level of bone remodeling processes which was manifested in slowing of thinning of bone trabeculas and in prevention of possible microfractures in them.
Figure 1. Results of the effect of the studied medicines on bone tissue blood supply 8 weeks after bilateral ovariectomy.
Note. Hereinafter: * – p<0.05 as compared to the group of intact animals; ** – p<0.05 as compared to the group of rats with osteoporosis.
Figure 2. The results of the impact of medicines on the width of bone trabeculas.
Figure 3. The results of the effect of combinations of medicines on the blood supply of the bone tissue.
Figure 4. The results of the effect of combinations of drugs on the width of bone trabeculas.
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Информация для цитирования:
Koklina, N.Y. The study of osteoprotective properties of nanoparticulated forms of resveratrol and losartan / N.Y. Koklina, O.S. Gudyrev, A.V. Faitelson // Research result: pharmacology and clinical pharmacology. – 2015. – Vol. 1, №1 (1). – P. 28-33. doi: 10.18413/2500-235X-2015-1-4-32-38