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Research Result: Pharmacology and Clinical Pharmacology

Том 4, Выпуск №1, 2018

ON MECHANISM OF ANTIARRHYTHMIC ACTION OF SOME DIMETHYLPHENYLACETAMIDE DERIVATIVES

Yahya Mohamed H.S., Kurganov Nikolay A., Blinova Ekaterina V., Semeleva Elena V., Lebedev Arkadiy B., Blinov Dmirty S., Novikov Andrei V.
Abbreviations: AC – acetylcholyne; AF – atrial fibrillation; AP – action potential; BLM – bi-lipid membrane; DPA – Dimethylphenylacetamide; VA – ventricular arrhythmia Introduction: The study aim was ...

INVESTIGATION OF THE ACTIVITY OF NEW DERIVATIVES OF 1,3-DIAZINONE-4 AND THEIR ACYCLIC PRECURSORS WITH RESPECT TO BACTERIA OF THE GENUS PROTEUS

Luzhnova Svetlana A., Voronkov Andrey V., Gabitova Narmina M., Billel Souda 
Introduction: The present paper provides a study of the activity of the new 1,3-diazinon-4 derivatives and their acyclic precursors under the laboratory cipher PYaTd1, PYaTs2, PYaTs3 and PYaTs4 against ...

RENAL CELL CARCINOMA DRUG AND CELL THERAPY: TODAY AND TOMORROW

Pushkin Anton A., Burda Youri E., Sevast'yanov Aleksandr A., Kulikovskiy Vladimir F., Burda Svetlana Yu., Golubinskaya Polina A., Zvyagina Alina K., Kulyushina Natal'ya V.
Today, considerable progress in the renal cell carcinoma (RCC) treatment has been made due to development of targeted and immunotherapeutic approaches to the RCC treatment, especially in metastasising carcinoma. In the ...

NEW METHODS TO DETECT EARLY MANIFESTATIONS OF ADVERSE SIDE EFFECTS OF GLUCOCORTICOSTEROIDS IN CHILDREN

Batishcheva Galina A., Zhdanova Olga A., Nastausheva Tatiana L., Goncharova Nataliya Y., Chernov Yury N.
Introduction: The article focuses on the early manifestations of adverse side effects in children with nephrotic syndrome receiving glucocorticosteroids. The search for criteria of early side effect manifestations is ...

METHODICAL APPROACHES TO BIOASSAY OF SUBSTANCES CONTAINING UNSTABLE FUNCTIONAL GROUPS

Khokhlov Alexander L., Yaichkov Ilya I., Dzhurko Yuriy A., Shitov Leonid N., Shitova Anastasia M.
Introduction: This article describes the method development approaches for bioassay of substances containing unstable functional groups and forming unstable metabolites using the example of mycophenolic acid, methyldopa and mebeverine ...

CORRECTION OF ISCHEMIC OPTIC NEUROPATHY IN RATS BY CARBAMYLATED DARBEPOETIN

Peresypkina Anna A.
Introduction: The protective effects of carbamylated darbepoetin on the model of ischemic optic neuropathy in rats were revealed. Objectives: To increase the effectiveness of pharmacological correction of experimental ischemic optic ...

MELATONIN AS AN EFFECTIVE PHARMACOCORRECTOR OF ALIMENTARY OBESITY RESULTING FROM A LONG-TERM EXCESSIVE INTAKE OF PALM OIL

Bibik Elena Yu, Shipilova Natalia V., Demenko Andrey V.
Introduction: In the modern world, the problem of alimentary obesity is becoming one of the global problems affecting all countries. Desynchronosis of bodily rhythms is another possible cause of ...

CORRECTION OF MORPHOFUNCTIONAL DISTURBANCES ARISING WHEN MODELLING PREECLAMPSIA WITH RESVERATROL AND NICORANDIL

Stupakova Elena G., Lazareva Galina A., Gureev Vladimir V.
Introduction: Preeclampsia is one of the most serious diseases of the second half of pregnancy and is surely amongst the top three causes of maternal mortality. Therefore, the creation ...

ENDOTHELIAL DYSFUNCTION: COMPARATIVE EVALUATION OF ULTRASOUND DOPPLEROGRAPHY, LASER DOPPLERFLOWMETRY AND DIRECT MONITORING OF ARTERIAL PRESSURE FOR CONDUCTING PHARMACOLOGICAL TESTS IN RATS

Soldatov Vladislav O., Malorodova Tatyana N., Balamutova Tatiana I., Ksenofontov Andrey O., Dovgan Anton P., Urozhevskaya Zhanna S.
Introduction: The importance of the problem of endothelial dysfunction makes it essential to improve approaches to its evaluation. Due to the high diagnostic potential of ultrasound dopplerography, this method ...

DOXORUBICIN-ASSOCIATED СARDIOMYOPATHY: NEW APPROACHES TO PHARMACOLOGICAL CORRECTION USING 3-(2,2,2-TRIMETHYLHYDRAZINIUM) PROPIONATE DERIVATIVES

Danilenko Lyudmila M.
Introduction: The search for new compounds with cardioprotective activity amongst the 3-(2,2,2-trimethylhydrazinium) propionate derivatives looks promising. Research objectives: to study cardioprotective effects of the 3-(2,2,2-trimethylhydrazinium) propionate derivatives. <p ...