Главная
12+

Research Result: Pharmacology and Clinical Pharmacology

Том 4, Выпуск №2, 2018

ENDOTHELOTROPIC ACTIVITY OF 4-HYDROXY-3,5-DI-TRET-BUTYLCINNAMIC ACID IN THE CONDITIONS OF EXPERIMENTAL CEREBRAL ISCHEMIA

Voronkov Andrey V., Pozdnyakov Dmitrij I.
Introduction: The aim of the study was to evaluate the endothelioprotective activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in conditions of experimental cerebral ischemia. Materials and Methods: The brain ischemia was ...

IMIDAZOLINE RECEPTORS AGONISTS: POSSIBLE MECHANISMS OF ENDOTHELIOPROTECTION

Soldatov Vladislav O., Shmykova Elena A., Pershina Marina A., Ksenofontov Andrey O., Zamitsky Yaroslav M., Kulikov Aleksandr L., Peresypkina Anna A., Dovgan Anton P., Belousova Yulia V.
Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In this review, the historical, physiological, pathophysiological aspects concerning imidazoline ...

2-AMINOAETHANESULFONIC ACID COMPOUNDS POSSESS PROTECTIVE PROPERTY IN REPERFUSION-INDUCED HEART INJURY

Kurganov Nikolay A., Blinova Ekaterina V., Semeleva Elena V., Gromova Irina A., Blinov Dmirty S., Novikov Andrei V., Mashkova Julija N., Vasilkina Olga V.
The study aim was to explore pharmacological effects of 2-aminoaethansulfonic acid compounds in reperfusion-induced heart injury. Materials and methods. The study was performed on rats and dogs of ...

ASSESSMENT OF PHARMACOLOGICAL ACTIVITY AND BIOAVAILABILITY OF THE NEW DERIVATIVE 1,3,4-THIADIAZOLE

Popov Nikita S., Demidova Marina A., Malygin Alexandr S.
Introduction: Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid. Materials and Methods: In animal experiments, acute toxicity, pharmacological activity and bioavailability of acexazolamide were ...