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Research Results in Pharmacology

Том 4, Выпуск №2, 2018

ENDOTHELOTROPIC ACTIVITY OF 4-HYDROXY-3,5-DI-TRET-BUTYLCINNAMIC ACID IN THE CONDITIONS OF EXPERIMENTAL CEREBRAL ISCHEMIA

Introduction: The aim of the study was to evaluate the endothelioprotective activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in conditions of experimental cerebral ischemia. Materials and methods: The brain ischemia was ...

IMIDAZOLINE RECEPTORS AGONISTS: POSSIBLE MECHANISMS OF ENDOTHELIOPROTECTION

Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In this review, the historical, physiological, pathophysiological aspects concerning imidazoline receptor ...

ASSESSMENT OF PHARMACOLOGICAL ACTIVITY AND BIOAVAILABILITY OF THE NEW DERIVATIVE 1,3,4-THIADIAZOLE

Introduction: Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid. Materials and Methods: In animal experiments, acute toxicity, pharmacological activity and bioavailability of acexazolamide were evaluated. Anti-inflammatory ...

PRINCIPLES OF PHARMACOLOGICAL CORRECTION OF PULMONARY ARTERIAL HYPERTENSION

Definition and classification: Pulmonary hypertension (PH) is a group of life-threatening progressive diseases of various genesis, characterized by a progressive increase in arterial pressure (AP) in the pulmonary artery ...

DISORDERS OF THE IMMUNE STATUS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA; DIFFERENTIATED PHARMACOLOGICAL CORRECTION

Introduction: Chronic cerebral ischemia (CCI) accounts for 60-75% of all cerebrovascular diseases in Russia and around the world. The problem: the issues concerning the role of immunity in the pathogenesis ...

PHARMACOLOGICAL SCREENING OF SUBSTANCES WITH CARDIOPROTECTIVE EFFECT IN THE GROUP OF 3-OXYPYRIDINE DERIVATIVES

Introduction: The search for new compounds with antihypoxic and cardioprotective effects among 3-oxypyridine derivatives is promising. Research objectives: To study the anti-hypoxic and cardioprotective effects of 3-oxypyridine derivatives. ...