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Research Results in Pharmacology

Том 4, Выпуск №2, 2018

ENDOTHELOTROPIC ACTIVITY OF 4-HYDROXY-3,5-DI-TRET-BUTYLCINNAMIC ACID IN THE CONDITIONS OF EXPERIMENTAL CEREBRAL ISCHEMIA

Voronkov Andrey V., Pozdnyakov Dmitrij I.
Introduction: The aim of the study was to evaluate the endothelioprotective activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in conditions of experimental cerebral ischemia. Materials and methods: The brain ischemia was ...

IMIDAZOLINE RECEPTORS AGONISTS: POSSIBLE MECHANISMS OF ENDOTHELIOPROTECTION

Soldatov Vladislav O., Shmykova Elena A., Pershina Marina A., Ksenofontov Andrey O., Zamitsky Yaroslav M., Kulikov Aleksandr L., Peresypkina Anna A., Dovgan Anton P., Belousova Yulia V.
Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In this review, the historical, physiological, pathophysiological aspects concerning imidazoline receptor ...

2-AMINOAETHANESULFONIC ACID COMPOUNDS POSSESS PROTECTIVE PROPERTY IN REPERFUSION-INDUCED HEART JNJURY

Kurganov Nikolay A., Blinova Ekaterina V., Semeleva Elena V., Gromova Irina A., Blinov Dmirty S., Novikov Andrei V., Mashkova Julija N., Vasilkina Olga V.
The study aim was to explore pharmacological effects of 2-aminoaethansulfonic acid compounds in reperfusion-induced heart injury. Materials and methods. The study was performed on rats and dogs of both ...

ASSESSMENT OF PHARMACOLOGICAL ACTIVITY AND BIOAVAILABILITY OF THE NEW DERIVATIVE 1,3,4-THIADIAZOLE

Popov Nikita S., Demidova Marina A., Malygin Alexandr S.
Introduction: Acexazolamide is a new derivative of 1,3,4-thiadiazole and acexamic acid. Materials and Methods: In animal experiments, acute toxicity, pharmacological activity and bioavailability of acexazolamide were evaluated. Anti-inflammatory ...

ANALYSIS OF CHANGES IN PHARMACOTHERAPY OF STABLE ANGINA OVER THE FIVE-YEAR PERIOD AT SPECIALIZED OUT-PATIENT LEVEL OF MEDICAL CARE (PHARMACOEPIDEMIOLOGICAL STUDY)ANALYSIS OF CHANGES IN PHARMACOTHERAPY OF STABLE ANGINA OVER THE FIVE-YEAR PERIOD AT SPE

Tsukanova Kristina , Fitilev Sergey , Vozzhaev Alexandr , Shkrebneva Irina , Klyuev Dmitry 
Introduction: Ischemic heart disease (IHD) remains the leading cause of death both in Europe and in Russia. The most common form of IHD is stable angina. There is compelling evidence that ...

PRINCIPLES OF PHARMACOLOGICAL CORRECTION OF PULMONARY ARTERIAL HYPERTENSION

Korokina Liliya V., Zhernakova Nina I., Korokin Michael V., Pokopejko Olga N.
Definition and classification: Pulmonary hypertension (PH) is a group of life-threatening progressive diseases of various genesis, characterized by a progressive increase in arterial pressure (AP) in the pulmonary artery ...

THE EFFECT OF DERIVATIVES OF TETRAHYDROPYRIDO[2,1-B][1,3,5] THIADIAZINE ON HEMATOLOGIC INDICES OF RATS WITH SUBACUTE PAROTITISTHE EFFECT OF DERIVATIVES OF TETRAHYDROPYRIDO[2,1-B][1,3,5] THIADIAZINE ON HEMATOLOGIC INDICES OF RATS WITH SUBACUTE PAROTIT

Bibik Elena Yu, Yaroshevskaya Oksana G., Demenko Andrey V., Frolov Konstantin A., Dotsenko Victor V., Kryvokolysko Sergey G.
Introduction: Regardless of belonging of NSAIDs to one or another chemical group, they all have common side effects that can occur when using these drugs for a long or ...

EXPERIMENTAL AND CLINICAL STUDY OF THE EFFICACY OF MEDICINES CONTAINING OMEGA-3 AND 6 POLYUNSATURATED FATTY ACIDS, IN THE TREATMENT OF INFLAMMATORY SKIN DISEASESEXPERIMENTAL AND CLINICAL STUDY OF THE EFFICACY OF MEDICINES CONTAINING OMEGA-3 AND 6 POL

Grebennikova Svetlana V., Maklyakov Yuriy S.
Introduction: Over the recent years, the attention of scientists regarding the search for alternative means of treatment, including local therapy, of inflammatory skin diseases, has been focused in recent ...

PHARMACOLOGICAL CORRECTION OF INTRARENAL HEMODYNAMIC DISORDERS IN ACUTE KIDNEY INJURY (PART 2)

Shramenko Katherine K., Gorodnik Georgiy A., Shano Valentina P., Kuznetsova Irina V., Grigorenko Aleksandr P., Potapov Vladimir V.
Introduction: Treatment of acute kidney injury (AKI) is a complex current problem. Mortality in this pathology is over 50%. One of the areas of correction therapy in AKI patients is the ...

DISORDERS OF THE IMMUNE STATUS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA; DIFFERENTIATED PHARMACOLOGICAL CORRECTION

Shulginova Anastasia A., Konoplya Alexander I., Bystrova Natalya A.
Introduction: Chronic cerebral ischemia (CCI) accounts for 60-75% of all cerebrovascular diseases in Russia and around the world. The problem: the issues concerning the role of immunity in the pathogenesis ...

PHARMACOLOGICAL SCREENING OF SUBSTANCES WITH CARDIOPROTECTIVE EFFECT IN THE GROUP OF 3-OXYPYRIDINE DERIVATIVES

Danilenko Lyudmila M., Skachilova Sophia Ya., Nadezhdin Sergey V., Timokhina Alena S., Shcheblykina Olesya V., Kotelnikova Alla S.
Introduction: The search for new compounds with antihypoxic and cardioprotective effects among 3-oxypyridine derivatives is promising. Research objectives: To study the anti-hypoxic and cardioprotective effects of 3-oxypyridine derivatives. ...

2-PHENYL-1-(3-PYRROLIDIN-1-IL-PROPYL)-1 H-INDOLE HYDROCHLORIDE (SS-68): ANTIARRHYTHMIC AND CARDIOPROTECTIVE ACTIVITY AND ITS MOLECULAR MECHANISMS OF ACTION (PART I)

Bogus Saida K., Galenko-Yaroshevsky Pavel A., Suzdalev Konstantin P., Sukoyan Galina V., Abushkevich Valery G.
Introduction: The problem of heart rhythm disturbances is one of the most urgent topics of modern cardiology. According to the currently available concepts, 1,2- and 1,3-disubstituted aminoindole derivatives, which ...