Research Result: Pharmacology and Clinical Pharmacology
Том 3, Выпуск №3, 2017
EXPERIMENTAL PHARMACOLOGY
POSSIBLE WAYS OF PHARMACOLOGICAL CORRECTION OF ISCHEMIC DAMAGE TO THE LIVER WITH THE AGONIST OF PERIPHERAL IMIDAZOLINE RECEPTORS C7070
Introduction: We glad to introduce several variants of pharmacological correction of ischemic hepatic injury by imidazoline I2 receptor agonistС7070. Materials and methods: The experiment was carried out on ...
RESEARCH OF WOUND HEALING EFFECT OF PHYTOMINERALSORBENT ON THE BASIS OF MONTMORILLONITE
Introduction: The results of preclinical investigation of the wound healing effect of phytomineralsorbent (PMS) based on montmorillonite are presented. Objectives: Study of the possibilities of pharmacological correction of ...
TADALAFIL AS AN AGENT OF PHARMACOLOGICAL PRECONDITIONING IN ISCHEMIC - REPERFUSION BRAIN INJURY
Introduction: Ischemic stroke or cerebral infarction is the main pathology among severe forms of vascular lesions of the brain. One of the more effective non-medicamental methods of treatment is ...
PRECLINICAL STUDY OF PHARMACOLOGICAL ACTIVITY OF ENTEROSORBENTE ON THE BASIS OF MONTMORILLONITE
Introduction: At present, enterosorbents based on mineral raw materials are in high demand among the population. However, there are no enterosorbents on the Russian pharmaceutical market on the basis ...
CLINICAL PHARMACOLOGY
NEW APPROACHES TO PREVENTION OF NSAID-GASTROPATHY
Introduction: At present, the issue of gastric mucosal damage, induced by the use of non-steroidal anti-inflammatory drugs, remains unresolved. Objectives: The development of new methods of prevention of ...
EVALUATION OF THE INFLUENCE OF COMBINATIONS OF DRUGS FOR GENERAL ANESTHESIA ON CHANGE OF ACTIVITY OF STRESS-LIMITING AND STRESS-REALIZING LINKS ON THE CLINICAL MODEL OF ACUTE STRESS DAMAGE
Introduction: When a person is in a state of anesthesia - sedation, the realization of the stress reaction is carried out through the mesocortical - limbic system, while performing ...
INTERLEUKIN-6 IS A POTENTIAL TARGET FOR A CORRECTION OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH LOW-GRADE SYSTEMIC INFLAMMATION
Introduction: One of pathogenetic links of development of endothelial dysfunction, as an early marker of cardiovascular disease and comorbidity, is a low-grade systemic inflammation. In this regard, correction of ...
COMPLEX CORRECTION OF PSYCHOEMOTIONAL AND IMMUNOLOGICAL CHANGES IN PATIENTS WITH ACNE
Introduction: The problem of complex therapy of acne attracts the attention of researchers because it accompanied with significant cosmetic defect and caused serious patient’s experiences. Objectives: The aim ...
PHARMACOLOGICAL CORRECTION OF INTERCEPT HEMODYNAMICS IN ACUTE KIDNEY DAMAGE (PART 1)
Introduction: Development of vasoconstriction of kidney arterioles and reduction of renal blood flow is one of the main mechanism of acute kidney injury (AKI) formation. Methods for evaluation of ...
ADAPTIVE DESIGN IN CLINICAL DEVELOPMENT OF NEXT-IN-CLASS DRUGS
Introduction: The next-in-class drugs are the original drugs that by chemical structure and mode of action similar to their predecessors of the same pharmacological group. The clinical development of ...
PHARMACOLOGYCAL REVIEWS
LIPID DISTRESS-SYNDROME AND PROSPECTS OF ITS CORRECTION BY STATINES
Endothelial dysfunction in peritonitis: The formed concept of lipid distress syndrome (LDS) allows us to develop a working hypothesis on the key role of endothelial dysfunction in the aggressive ...
STATE SUPPORT FOR RESEARCH IN PHARMACOLOGY: AN ANALYSIS OF FOREIGN AND DOMESTIC EXPERIENCE
Introduction: The goal of research was to analyze the management of innovative activities for innovative medicines market launch in Russia and abroad. Materials and methods: In the study ...
