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Research Result: Pharmacology and Clinical Pharmacology

Том 3, Выпуск №4, 2017
EDITORIAL

OSWALD SCHMIEDEBERG –THE “FATHER” OF EXPERIMENTAL PHARMACOLOGY

Pokrovskii Mikhail V., Avtina Tatiana V., Zakharova Elena V., Belousova Yulia V.
Biography. Oswald Schmiedeberg (1838-1921) was a son of a bailiff and a maid of honour, the eldest of the six children in the family. He was born and educated ...
EXPERIMENTAL PHARMACOLOGY

STUDY OF ANALEPTIC ACTIVITY OF TETRAHYDROPYRIDO [2,1-B] [1,3,5] TIADIAZINE DERIVATIVES

Bibik Elena Yu, Saphonova Anna A., Yeryomin Anton V., Frolov Konstantin A., Dotsenko Victor V., Krivokolysko Sergey G.
Abstract Introduction: Our goal is to conduct an investigation of the analeptic activity of the tetrahydropyrido [2,1-b] [1,3,5] thiadiazine derivative group. Materials and methods: Biological studies were ...

ANTI-INFLAMMATORY AND ANALGESIC PROPERTIES OF SS-68 INDOLE DERIVATIVE

Bogus Saida K., Suzdalev Konstantin P., Galenko-Yaroshevsky Pavel A., Vasilev P. M., Vinakov Dmitry V., Kiseleva N. V., Kochetkov А. N., Kiselev А. V.
The experiments with rats show that when administered intravenously (5 mg/kg) and intragastrically (5, 10, 15 and 20 mg/kg), SS-68 compound exerts an anti-inflammatory effect (AIE) on models of ...

PHARMACOTHERAPEUTIC STRATEGIES FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH USE OF STATINES IN SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE

Denisiuk Tatiana A.
Objectives: The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are not fully developed. Goal: Determination of statins’ new pharmacological ...

LIGAND OF PERIPHERAL IMIDAZOLINE RECEPTORS BASED ON AMIDES OF HETEROCYCLIC ACIDS C7070: EFFECT ON ISHEMIZED TISSUES

Dovgan Anton P.
Introduction: In this regard, the study of pleiotropic hepatoprotective properties of the agonist of peripheral imidazoline receptors C7070 seems interesting from an applied point of view. Materials and ...

STUDY OF PHARMACOLOGICAL ACTIVITY OF NIGELLA DAMASCENA FIXED OIL IN EXPERIMENT

Efremova Marina P., Ivasheva Aelita V., Korokin Michael V.
Abstract Introduction: Literature data, rich chemical macro-microelement composition set the stage for experimental pharmacological study of adaptogene and lipid protective activity of Nigella damascena essential oil. Objectives: study of pharmacological ...

INTERACTION BETWEENSOME ANTIBIOTICS AND ANTIOXIDANTS

Miroshnichenko Alexandr G., Perfiliev Vyacheslav Yu., Lysenko Ilya V., Zhernakova Nina I.
Introduction: The bactericidal action of many antibacterial agents has a common mechanism associated with the generation of hydroxyl radicals and the activation of oxidative stress. This is confirmed by ...

CORRECTION OF RETINAL ANGIOPATHY OF HYPERTENSIVE TYPE BY DIMETHYLAMINOETHANOL DERIVATIVE 19-16 IN EXPERIMENT

Peresypkina Anna A.
Introduction: 63% of hypertensive patients have evidence of hypertensive angiopathy. Increase of effectiveness of drug therapy of retinal angiopathy of hypertensive type is an important task of pharmacology. <p ...

STUDY OF PHARMACOLOGICAL ACTIVITY IN SUBLIMATED CULTURE LIQUID OF ALLOGENIC, XENOGENEIC HEPATOCYTES AND FIBROBLASTS FOR THE CORRECTION OF LIVER DAMAGES IN CARBON TETRACHLORIDE INTOXICATION

Razumova Marina S., Litvinova Ekaterina S., Gavriliouk Vassili P.
Introduction: At the present time many clinical and experimental studies are devoted to the correction of hepatocytes and liver functional abnormalities with the use of cellular technologies. Materials ...

EFFECT OF PHARMACOLOGICAL PRECONDITIONING WITH INCRETINOMIMETICS EXENATIDE AND VILDAGLIPTIN ON THE SURVIVAL OF ISCHEMIC TISSUES

Tarasova Alla Pavlovna, Danilenko Lyudmila M., Sernov Lev Nikolaevich
Introduction: Currently, much attention is paid to the pleiotropic effects of entretenimiento. Purposes: Study of the protective effect exenatide and valdiation with pharmacological correction of ischemic myocardial damage, ...

THE EFFECT OF NEW FORMS FOR EXTERNAL APPLICATION ON THE VASODILATING FUNCTION OF THE ENDOTHELIUM AND THE CONCENTRATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASES IN RATS WITH AN EXPERIMENTAL MODEL OF A PATHOLOGICAL SCAR AT EARLY HEALING TIMES

Voronkov Andrey V., Gamzeleva Olesya Yu.
Introduction: According to statistical data, the tendency towards an increase in the number of patients with keloid and hypertrophic scars at the site of skin lesions remains in the ...
CLINICAL PHARMACOLOGY

OPTIMIZATION IMMUNEPHARMACOTHERAPY OF PYOINFLAMMATORY DISEASES

Zemskova Veronica A., Zoloedov Vladimir I., Popova Olesya A.
Introduction: The results of clinical investigation of several pyoinflammatory diseases are presented. Objectives: On clinical data of various models of pyoinflammatory diseases - deep pyodermia (UCP), chronic salpingooforitis ...