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EXPERIMENTAL PHARMACOLOGY

LIGAND OF PERIPHERAL IMIDAZOLINE RECEPTORS BASED ON AMIDES OF HETEROCYCLIC ACIDS C7070: EFFECT ON ISHEMIZED TISSUES

Том 3, Выпуск №4, 2017
Introduction: In this regard, the study of pleiotropic hepatoprotective properties of the agonist of peripheral imidazoline receptors C7070 seems interesting from an applied point of view. Materials and ...

PHARMACOTHERAPEUTIC STRATEGIES FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH USE OF STATINES IN SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE

Том 3, Выпуск №4, 2017
Objectives: The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are not fully developed. Goal: Determination of statins’ new pharmacological ...

INTERACTION BETWEENSOME ANTIBIOTICS AND ANTIOXIDANTS

Том 3, Выпуск №4, 2017
Introduction: The bactericidal action of many antibacterial agents has a common mechanism associated with the generation of hydroxyl radicals and the activation of oxidative stress. This is confirmed by ...

CORRECTION OF RETINAL ANGIOPATHY OF HYPERTENSIVE TYPE BY DIMETHYLAMINOETHANOL DERIVATIVE 19-16 IN EXPERIMENT

Том 3, Выпуск №4, 2017
Introduction: 63% of hypertensive patients have evidence of hypertensive angiopathy. Increase of effectiveness of drug therapy of retinal angiopathy of hypertensive type is an important task of pharmacology. <p ...

EFFECT OF PHARMACOLOGICAL PRECONDITIONING WITH INCRETINOMIMETICS EXENATIDE AND VILDAGLIPTIN ON THE SURVIVAL OF ISCHEMIC TISSUES

Том 3, Выпуск №4, 2017
Introduction: Currently, much attention is paid to the pleiotropic effects of entretenimiento. Purposes: Study of the protective effect exenatide and valdiation with pharmacological correction of ischemic myocardial damage, ...

STUDY OF PHARMACOLOGICAL ACTIVITY OF NIGELLA DAMASCENA FIXED OIL IN EXPERIMENT

Том 3, Выпуск №4, 2017
Abstract Introduction: Literature data, rich chemical macro-microelement composition set the stage for experimental pharmacological study of adaptogene and lipid protective activity of Nigella damascena essential oil. Objectives: study of pharmacological ...

TADALAFIL AS AN AGENT OF PHARMACOLOGICAL PRECONDITIONING IN ISCHEMIC - REPERFUSION BRAIN INJURY

Том 3, Выпуск №3, 2017
Introduction: Ischemic stroke or cerebral infarction is the main pathology among severe forms of vascular lesions of the brain. One of the more effective non-medicamental methods of treatment is ...

RESEARCH OF WOUND HEALING EFFECT OF PHYTOMINERALSORBENT ON THE BASIS OF MONTMORILLONITE

Том 3, Выпуск №3, 2017
Introduction: The results of preclinical investigation of the wound healing effect of phytomineralsorbent (PMS) based on montmorillonite are presented. Objectives: Study of the possibilities of pharmacological correction of ...

PLEYOTROPIC ANTIAGGREGANT EFFECTS OF AN INNOVATIVE ANTIARRHYTHMIC OF CLASS III SS-68, AN INDOLE DERIVATIVE

Том 3, Выпуск №2, 2017
Background: A new indole derivative with the lab code-number SS-68 demonstrates a significant antiarrhythmic (anti-fibrillation) activity associated with the predominant influence on potassium and calcium conductivity of cardiomyocytes plasmalemmas. ...

EXPERIMENTAL RATIONALE FOR THE USE OF FLUIDS WITH DIFFERENT REDOX POTENTIAL AS A BASIS FOR INFUSION THERAPY

Том 3, Выпуск №2, 2017
Introduction: The hypothesis is that a change in the redox potential (Red-Ox) of infusion solutions can increase their pharmacological efficacy. Objectives: To study the parameters of redox potential (ORP ...
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