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  • ContentsContents
  • Article InfoArticle Info
  • CitationCitation
  • MetricsMetrics
  • CommentComment
  • RelatedRelated
  • FigsFigs
  • TabsTabs
  • RefsRefs
  • CitedCited
  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
  • Results
    • Genetic analysis of the HPRT1 gene in our patient
    • Structural modeling of HPRT1 del8Val loss of function mutation by bioinformatic algorithms
    • Developing a system for gene editing
    • Generation and genetic analysis of primary genetically modified animals
    • Generation and genetic analysis of F1 genetically modified animals
  • Discussion
  • Conclusion
  • Conflicts of interests
  • Acknowledgements
  • References
  • Author Contributors
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