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  • ContentsContents
  • Article InfoArticle Info
  • CitationCitation
  • MetricsMetrics
  • CommentComment
  • RelatedRelated
  • FigsFigs
  • TabsTabs
  • RefsRefs
  • CitedCited
  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Animals
    • Investigated chemical compounds
    • The study design included the following steps
    • Drug administration
    • Acute toxicity evaluation
    • Neurotoxicity evaluation
      • Rotarod test
      • Bar test
    • Behavioral tests (behavioral research)
      • Open field test
      • Dark/light transition test
    • Anti-epileptic models
      • Seizures induced by maximal electroshock (MES) in mice
      • Pentylenetetrazole induced seizures (scPTZ) in mice
      • The therapeutic index
    • Analgesic activity
      • Hot-plate test
      • Biochemical studies Determination of GABA and N- (5-ethyl-1,3,4-thiadiazol-2-yl) -2-propylpentanamide content in rat brain
      • Statistical analysis
  • Results and discussion
    • Design of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid
    • Assessment of acute toxicity and neurotoxicity of VPZ
    • Study of the behavior of mice in the open field test and light/dark transition test
    • Assessment of antiepileptic activity of VPZ
    • Study of analgesic activity of VPZ
  • Conclusion
  • Conflict of interests
  • References
  • Author contributions
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