Research Article
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Article title
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Abstract
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Keywords
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Introduction
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Materials and methods
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Animals
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Investigated chemical compounds
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The study design included the following steps
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Drug administration
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Acute toxicity evaluation
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Neurotoxicity evaluation
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Rotarod test
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Bar test
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Behavioral tests (behavioral research)
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Open field test
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Dark/light transition test
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Anti-epileptic models
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Seizures induced by maximal electroshock (MES) in mice
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Pentylenetetrazole induced seizures (scPTZ) in mice
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The therapeutic index
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Analgesic activity
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Hot-plate test
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Biochemical studies Determination of GABA and N- (5-ethyl-1,3,4-thiadiazol-2-yl) -2-propylpentanamide content in rat brain
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Statistical analysis
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Results and discussion
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Design of a new 1,3,4-thiadiazolylamide derivative of 2-propylpentanoic acid
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Assessment of acute toxicity and neurotoxicity of VPZ
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Study of the behavior of mice in the open field test and light/dark transition test
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Assessment of antiepileptic activity of VPZ
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Study of analgesic activity of VPZ
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Conclusion
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Conflict of interests
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References
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Author contributions