Research Article
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Article title
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Abstract
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Keywords
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Introduction
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Materials and methods
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Materials
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Synthesis
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Synthesis of 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione (HSV-DKH-0450)
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Stage 1. 2,2-Dimethyl-5-[(4-methyl-1,3-thiazol-5-yl)methylene]-1,3-dioxane-4,6-dione
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Stage 2. 3-[4-(2-Chlorophenyl)-2-hydroxy-6-oxocyclohex-1-en-1-yl]-3-(4-methyl-1,3-thiazol-5-yl)propanoate
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Stage 3. 7-(2-chlorophenyl)-4-(4-methyl-1,3-thiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5 (1H, 3H)-dione (HSV-DKH-0450)
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ADMET study
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Pharmacological research
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Molecular docking
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Results and discussion
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Conclusion
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Funding
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Conflict of interest
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References
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Author contributions