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  • ContentsContents
  • Article InfoArticle Info
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  • Article title
  • Abstract
  • Keywords
  • Introduction
  • Materials and methods
    • Materials
    • Synthesis
    • Synthesis of 7-(2-chlorophenyl)-4-(4-methylthiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione (HSV-DKH-0450)
      • Stage 1. 2,2-Dimethyl-5-[(4-methyl-1,3-thiazol-5-yl)methylene]-1,3-dioxane-4,6-dione
      • Stage 2. 3-[4-(2-Chlorophenyl)-2-hydroxy-6-oxocyclohex-1-en-1-yl]-3-(4-methyl-1,3-thiazol-5-yl)propanoate
      • Stage 3. 7-(2-chlorophenyl)-4-(4-methyl-1,3-thiazol-5-yl)-4,6,7,8-tetrahydroquinoline-2,5 (1H, 3H)-dione (HSV-DKH-0450)
    • ADMET study
    • Pharmacological research
    • Molecular docking
  • Results and discussion
  • Conclusion
  • Funding
  • Conflict of interest
  • References
  • Author contributions
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