Research Results in Pharmacology 2(1): 20-24, doi: 10.18413/2313-8971-2016-2-1-20-24
STUDY OF THE INFLUENCE OF L-NORVALINE, ROSUVASTATIN AND THEIR COMBINATION ON THE LEVEL OF MICROCIRCULATION IN BONE TISSUE IN EXPERIMENTAL OSTEOPOROSIS AND FRACTURES ON ITS BACKGROUND
expand article infoSamuel Densingh, Oleg S. Gudyrev, Alexander V. Faitelson, Aleksandr A. Stepchenko, Alexandr A. Dolzhikov, Sergej V. Povetkin

Corresponding author: Samuel Densingh ( densingh7@gmail.com )

© 2018 Samuel Densingh, Oleg Gudyrev, Alexander Faitelson, Aleksandr Stepchenko, Alexandr Dolzhikov, Sergej Povetkin.
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Citation: Densingh S, Gudyrev O, Faitelson A, Stepchenko A, Dolzhikov A, Povetkin S (2016) STUDY OF THE INFLUENCE OF L-NORVALINE, ROSUVASTATIN AND THEIR COMBINATION ON THE LEVEL OF MICROCIRCULATION IN BONE TISSUE IN EXPERIMENTAL OSTEOPOROSIS AND FRACTURES ON ITS BACKGROUND. Research Results in Pharmacology 2(1): 20-24. https://doi.org/10.18413/2313-8971-2016-2-1-20-24
Open Access
Abstract
The experiment was carried out in female white Wistar rats to investigate the effect of L-norvaline, rosuvastatin and their combination on parameters of blood supply to the bone tissue on models of experimental osteoporosis and osteoporotic fractures. It was found that the studied drugs prevent reduction of microcirculation in osteoporotic bone tissue as well as in callus tissue of experimental osteoporotic fractures and it positively influences the course of reparative regeneration of bone tissue.
Keywords
osteoporosis, osteoporotic fracture, microcirculation, endothelial dysfunction, L-norvaline, rosuvastatin, Bivalos