Research Results in Pharmacology 2(1): 36-41, doi: 10.18413/2313-8971-2016-2-1-36-41
PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED OXIDE DEFICIENCY WITH DERIVATIVES OF 3-(2,2,2- TRIMETHYLHYDRAZINIUM) PROPIONATE
expand article infoSophiya Ya. Skachilova, Oleg G. Kesarev, Lyudmila Danilenko, Natalya A. Bystrova, Alexandr A. Dolzhikov, Sergej B. Nikolaev
Open Access
Abstract
This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have shown that 3-(2,2,2-trimethylhydrazinium) propionate and its derivatives reduced the expression of NOdeficient endothelial dysfunction induced by intraperitoneal administration of N-nitro L-arginine methyl ester (L-NAME), improved the parameters of endothelium-dependent vasodilation in response to administration of acetylcholine, and reduced the coefficient of endothelial dysfunction. It was revealed that the 5-hydroxinicotinate 3-(2,2,2-trimethylhydrazinium) potassium propionate has the most pronounced endothelioprotective effect.
Keywords
endothelial dysfunction, 3-(2, 2, 2-trimethylhydrazinium) propionate, L-NAME.