Rational antimicrobial chemotherapy: assessment of the level of basic knowledge of general practitioners. Final results of the KANT project

Roman A. Bontsevich; Anna V. Adonina; Anna A. Gavrilova; Yana R. Vovk; Maxim L. Maximov; Irina M. Martynenko; Vera A. Nevzorova; Galina G. Prozorova; Elena N. Bochanova; Olga G. Kompaniets; Valeriya O. Barysheva; Galina G. Ketova; Oksana V. Tsygankova

doi:10.3897/rrpharmacology.6.54855

Authors

Roman A. Bontsevich Children’s medical center “Azbuka Zdorovya”; Outpatient Clinic “Lyubimyy doktor” https://orcid.org/0000-0002-9328-3905
Anna V. Adonina Children’s medical center “Azbuka Zdorovya” https://orcid.org/0000-0002-9735-7270
Anna A. Gavrilova Outpatient Clinic “Garmoniya Zdorov’ya” LLC “MAKSBelmed” https://orcid.org/0000-0002-4335-5165
Yana R. Vovk Clinical and diagnostic center “Meditsina 31” https://orcid.org/0000-0002-7741-9745
Maxim L. Maximov Kazan State Medical Academy – Branch Campus of the Russian Medical Academy of Continuous Professional Education https://orcid.org/0000-0002-8979-8084
Irina M. Martynenko Pacific State Medical University https://orcid.org/0000-0002-5181-0279
Vera A. Nevzorova Pacific State Medical University https://orcid.org/0000-0002-0117-0349
Galina G. Prozorova Voronezh State Medical University named after N.N. Burdenko https://orcid.org/0000-0001-8675-1590
Elena N. Bochanova Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetskiy https://orcid.org/0000-0003-4371-2342
Olga G. Kompaniets Kuban State Medical University https://orcid.org/0000-0001-9449-9241
Valeriya O. Barysheva South Ural State Medical University https://orcid.org/0000-0001-7762-7854
Galina G. Ketova South Ural State Medical University https://orcid.org/0000-0002-4678-6841
Oksana V. Tsygankova Novosibirsk State Medical University; Institute of Internal and Preventive Medicine, Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences https://orcid.org/0000-0003-0207-7063

DOI:

https://doi.org/10.3897/rrpharmacology.6.54855

Abstract

Introduction: The irrational use of medicines leads to a decrease in the quality of care, an increase in treatment costs and side effects. In the case of antibacterial drugs, in addition to all the above-mentioned consequences, their improper use can lead to an aggravation of the existing and quite challenging problem of our time – the growth of antibiotic resistance among pathogenic microorganisms.

The aim of the study: to determine the level of basic knowledge of medical specialists in the field of a rational use of antimicrobial drugs (AMD).

Materials and methods: The study was based on an analysis of an anonymous multicenter survey in the framework of the KANT project (the full name of the project is “Physicians’ (Students’) Knowledge of Antimicrobials Usage”). It was conducted in 2018–2019 in 10 major centers of Russia.

Results and iscussion: According to the results of the study, the respondents showed a low level of knowledge of the rational use of antibacterial drugs. The best results are obtained for questions No.1 (time interval for evaluating the effectiveness of the initial antimicrobial therapy (AMT)), No.2 (rationality and period of AMD change with a positive clinical effect), and No.9 (determining the mode of using the proposed drugs), whereas the worst results were obtained for questions No.3 (determining irrational combinations of AMD), No.4 (determining a situation requiring a long course of AMT), and No.7 (choosing auxiliary drugs for bacterial respiratory infections).

Conclusion: The results obtained in the study indicate the need for additional educational activities among health professionals.

Keywords:

questionnaires, antimicrobials, general practitioner, rational antibiotic therapy, knowledge level, pharmacoepidemiology

Author Contribution

Roman A. Bontsevich, Children’s medical center “Azbuka Zdorovya”; Outpatient Clinic “Lyubimyy doktor”

MD, PhD, Associated Professor, pulmonologist, clinical pharmacologist and therapist.

Anna V. Adonina, Children’s medical center “Azbuka Zdorovya”

MD, pediatrician.

Anna A. Gavrilova, Outpatient Clinic “Garmoniya Zdorov’ya” LLC “MAKSBelmed”

MD, therapist.

Yana R. Vovk, Clinical and diagnostic center “Meditsina 31”

MD, therapist.

Maxim L. Maximov, Kazan State Medical Academy – Branch Campus of the Russian Medical Academy of Continuous Professional Education

MD, PhD, Professor, Head of the Department of Clinical Pharmacology and Pharmacotherapy.

Irina M. Martynenko, Pacific State Medical University

MD, PhD, Associate Professor, Institute of Therapy and Instrumental Diagnostics.

Vera A. Nevzorova, Pacific State Medical University

MD, PhD, Professor, Head of the Institute of Therapy and Instrumental Diagnostic.

Galina G. Prozorova, Voronezh State Medical University named after N.N. Burdenko

MD, PhD, Doctor Habil. of Medical Sciences, Professor, Department of Therapeutic Disciplines.

Elena N. Bochanova, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetskiy

MD, PhD Doctor Habil. of Medical Sciences, Associated Professor, Department of Pharmacology and Pharmaceutical Consulting with a Postgraduate Education Course

Olga G. Kompaniets, Kuban State Medical University

MD, PhD, Associated Professor, First Therapy Department.

Valeriya O. Barysheva, South Ural State Medical University

MD, PhD, Assistant Professor, Department of Outpatient Therapy and Clinical Pharmacology.

Galina G. Ketova, South Ural State Medical University

MD, PhD, Professor, Department of Outpatient Therapy and Clinical Pharmacology.

Oksana V. Tsygankova, Novosibirsk State Medical University; Institute of Internal and Preventive Medicine, Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences

MD, PhD, Professor, Department of Emergency Medicine with Endocrinology and Occupational Pathology of the Faculty of Continuing Education and Professional Retraining of Doctors.