First discovered positive effect of L-norvaline on the volume of small intestine tissues necrosis in a model of segmental mesenteric thrombosis in rats

Authors

DOI:

https://doi.org/10.18413/rrpharmacology.9.10022

Abstract

Introduction: Mesenteric thrombosis is a severe pathology with necrotization of intestinal tissues and death of the patient. The development of effective pharmacotherapy is an important task facing researchers.

Materials and Methods: All studies were performed on 42 female white rats of the Wistar line, weighing 250±25 g. Segmental mesenteric thrombosis was reproduced by ligation of three segmental arteries in the area of the ileum. The volume of necrosis was determined by the triphenyl tetrazolium method.

Results and Discussion: We have studied for the first time the effect of the arginase inhibitor L-norvaline on the volume of small intestine necrotized tissues in a model of acute segmental mesenteric thrombosis in rats. The study revealed a decrease in the volume of necrotic tissues from 32.39±0.47% to 23.84±0.39%, and the administration of glibenclamide did not cause complete cancellation of the L-norvaline action and led to a decrease in the volume of necrosis to 29.69±0.42%.

Conclusion: Arginase inhibitor L-norvaline has protective effect in intestinal ischemia

Graphical Abstract

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Keywords:

mesenteric thrombosis, L-norvaline, volume of necrotised tissues

References

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Author Contribution

Sergey A. Alekhin, Kursk State Medical University

PhD in Medicine, Associate Professor of the Department of Surgery №2, Kursk State Medical University; e-mail: s_alehin@mail.ru; ORCID ID: https://orcid.org/0000-0003-1429-7362. Planning the experiments, analyzing the literature and interpreting the data.

Elena N. Bezhina, Kursk State Medical University

Research assistant of the Department of Surgery №2, Kursk State Medical University; e-mail: elena_bejina@mail.ru;ORCID ID: https://orcid.org/0000-0003-3727-792X. The administration of the drugs to the animals and the modeling of acute intestinal ischemia.

Dmitry P. Nazarenko, Kursk State Medical University

Doctor Habil. of Medical Sciences, Professor, Professor of the Department of Surgery №2, Kursk State Medical University; e-mail: nazarenkodp003@yandex.ru; ORCID ID: https://orcid.org/0000-0002-2007-6825. Analyzing the literature and interpreting the data.

Leontiy V. Druzhikin, Belgorod State National Research University

Research assistant of the Department of Pharmacology and Clinical Pharmacology, Belgorod State National Research University; e-mail: l.druzhikin@mail.ru; ORCID ID: https://orcid.org/0000-0003-1238-7794. The administration of the drugs to the animals and the modeling of acute intestinal ischemia.

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Published

04-05-2023

How to Cite

Alekhin SA, Bezhina EN, Nazarenko DP, Druzhikin LV (2023) First discovered positive effect of L-norvaline on the volume of small intestine tissues necrosis in a model of segmental mesenteric thrombosis in rats . Research Results in Pharmacology 9(2): 17–19. https://doi.org/10.18413/rrpharmacology.9.10022

Issue

Vol. 9 No. 2 (2023)

Section

Short Communication

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