Diagnostic analysis of toxic damage due to a dose of zoledronic acid

Authors

DOI:

https://doi.org/10.18413/rrpharmacology.10.433

Abstract

Introduction: Comprehensive analysis is necessary to analyze the widespread use of bisphosphonate drugs in the treatment and prevention of various diseases of connective tissue structures. The relevance of the study depends on the impact they have on the patient’s somatic condition, given the number of early and late complications diagnosed by domestic and foreign clinicians.

Materials and methods: The methodology used was developed on Stavropol Regional Clinical Hospital from 2010 to 2022. A randomized and observational study of the state of connective tissue structures was conducted in 186 patients who had a history of taking zoledronic acid and developed bisphosphonate osteonecrosis of the jawbone. At the diagnostic and treatment stages, patients were tested using laboratory methods to monitor amino acids in biological fluids (blood), as well as bone blocks extracted intraoperatively using highly effective gas-liquid chromatography on AAA 500.

Results and discussion: Aminograms obtained in the pre-operative period indicate toxic effects of zoledronic acid on neuro, endocrine, and other human systems. The initiation and progression of aseptic inflammatory processes in tissue structures is correlated with the deteriorating general ocular status of patients when amino acids, such as alanine, serine, taurine, phenylalanine, tyrosine, proline, histidine, glycine, and valine, against a background of 90.4±2.1 mmol/L ammonia are reduced critically.

Conclusion: Zoledronic acid initiates an aseptic chronic inflammatory process in the jaw bones, accompanied by toxic acidosis, which worsens osteoporotic symptoms.

Graphical Abstract

Keywords:

amino acids, highly effective gas-liquid chromatography, jawbone resection

References

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Author Contribution

Irina V. Gabbasova, Stavropol State Medical University

Maxillofacial surgeon, Stavropol State Medical University Clinic of Endoscopic and Minimally Invasive Surgery, Stavropol, Russia; e-mail: dr.gabbasova-i@yandex.ru; ORCID ID https://orcid.org/0000-0003-3850-4274. Definition of key aims and objectives; preparation of histological material (surgery); analysis and interpretation of the data obtained; drafting of the manuscript and its editorial revision.

Valeria A. Sletova, Pyatigorsk Medical and Pharmaceutical Institute

Lecturer, Department of Pathology, Pyatigorsk Medical and Pharmaceutical Institute, Pyatigorsk, Russia; e-mail: tazler@yandex.ru; ORCID ID https://orcid.org/0000-0002-7026-3506. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comments.

Alina D. Oksentyuk, I.M. Sechenov First Moscow State Medical University

Assistant Professor, Department of Pediatric, Preventive Dentistry and Orthodontics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; e-mail: Oksentyuk_a_d@staff.sechenov.ru;  ORCID ID https://orcid.org/0000-0001-5490-1128. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comments.

Irina L. Abisalova, Pyatigorsk Medical and Pharmaceutical Institute

Candidate of Medical Sciences (PhD), Head of the Department of Pathology, Pyatigorsk Medical and Pharmaceutical Institute, Pyatigorsk, Russia; e-mail: irabi@yandex.ru; ORCID ID https://orcid.org/0000-0002-3828-6759. Search for and analysis of information; animal keeping control, preparation and sampling of material for research; and participation in the analysis of the research results.

Kristina S. Gandylian, Stavropol State Medical University

Kristina S. Gandylian, Candidate of Medical Sciences (PhD), Head of the Department of Surgical Dentistry and Maxillofacial Surgery, Stavropol State Medical University, Stavropol, Russia; e-mail: gandylian7@yandex.ru; ORCID ID https://orcid.org/0000-0003-3752-4752. Search for and analysis of information; animal keeping control, preparation and sampling of material for research; and participation in the analysis of the research results.

Zhou Ling, I.M. Sechenov First Moscow State Medical University

Residency student, Department of Pediatric, Preventive Dentistry and Orthodontics, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; e-mail: ling19980528@gmail.com;   ORCID ID https://orcid.org/0009-0009-1412-3689. Experimentation; analysis and interpretation of research results; and participation in scientific design.

Roman R. Saltovets, I.M. Sechenov First Moscow State Medical University

3rd year student, Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia; e-mail: saltovetsr898@mail.ru; ORCID ID https://orcid.org/0000-0001-5737-8694. Development and design of methodology, definition of the key aims and objectives, critical revision of the manuscript and its analysis, and provision of valuable comments.

Zhanna I. Glushanyan, Pyatigorsk Medical and Pharmaceutical Institute

Zhanna I. Glushanyan, 2nd-year student, Faculty of Medicine, Pyatigorsk Medical and Pharmaceutical Institute, Pyatigorsk, Russia; e-mail: zhannochka07@yandex.ru; ORCID ID https://orcid.org/0009-0006-9402-0492. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comments.

Hasan A. Ordashev, Dagestan State Medical University

Candidate of Medical Sciences (PhD), Head of the Department of Surgical Dentistry and Maxillofacial Surgery, Dagestan State Medical University, Makhachkala, Russia; e-mail: hasan005@mail.ru; ORCID ID https://orcid.org/0000-0002-4290-2665. Search for and analysis of information; animal keeping control, preparation and sampling of material for research; and participation in the analysis of the research results.

Arsen K. Shakhbanov, Dagestan State Medical University

Maxillofacial surgeon, Dagestan State Medical University, Makhachkala, Russia; e-mail: shahbanovars69@mail.ru; ORCID ID https://orcid.org/0009-0006-6637-3223. Search for and analysis of information; animal keeping control, preparation and sampling of material for research; and participation in the analysis of the research results.

Dmitry V. Mikhalchenko, Volgograd State Medical University

Holder of Advanced Doctorate (D.Sc.), Head of the Department of Propedeutics of Dental Diseases, Volgograd State Medical University, Volgograd, Russia; e-mail: mdmitriystom@yandex.ru; ORCID ID https://orcid.org/0000-0002-0479-8588. Development and design of methodology, definition of the key aims and objectives, critical revision of the manuscript and its analysis, and provision of valuable comments.

Said A. Shakhbanov, Dagestan State Medical University

Maxillofacial surgeon, Dagestan State Medical University, Makhachkala, Russia; e-mail: saidars96@mail.ru; ORCID ID https://orcid.org/0009-0001-3313-3729. Search for and analysis of information; animal keeping control, preparation and sampling of material for research; and participation in the analysis of the research results.

Biyke R. Isaeva, Dagestan State Medical University

Biyke R. Isaeva, Lecturer, Department of Surgical Dentistry and Maxillofacial Surgery, Dagestan State Medical University, Makhachkala, Russia; e-mail: isaevadrm@mail.ru; ORCID ID https://orcid.org/0009-0005-5449-4573. Search for and analysis of information; animal keeping control, preparation and sampling of material for research; and participation in the analysis of the research results.

Asiyat A. Idrisova, Dagestan State Medical University

Lecturer, Department of Surgical Dentistry and Maxillofacial Surgery, Dagestan State Medical University, Makhachkala, Russia; e-mail: 005asal@mail.ru; ORCID ID https://orcid.org/0009-0007-2734-0725. Search for and analysis of information; animal keeping control, preparation and sampling of material for research; and participation in the analysis of the research results.

Oleg I. Admakin, I.M. Sechenov First State Medical University

 Holder of Advanced Doctorate (D.Sc.), Professor, Department of Children and Preventive Dentistry, I.M. Sechenov First State Medical University, Moscow, Russia; e-mail: dr.admakinoi@yandex.ru; ORCID ID https://orcid.org/0000-0002-5626-2961. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comment.

Marina V. Loktionova, I.M. Sechenov First State Medical University

 Holder of Advanced Doctorate (D.Sc.), Associate Professor, Department of Children and Preventive Dentistry, I.M. Sechenov First State Medical University, Moscow, Russia; e-mail: marina_staff-sehenov@yandex.ru; ORCID ID https://orcid.org/0000-0003-3555-2035. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comments.

Oksana V. Vorobyeva, Belgorod State National Research University

Associate Professor of Biology, Belgorod State National Research University, Belgorod, Russia; e-mail: vorobyeva@bsu.edu.ru; ORCID ID https://orcid.org/0000-0003-0972-0074. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comments.

Tang Hui, Moscow State University of Medicine and Dentistry

Residency student, Department of Orthodontics, Moscow State University of Medicine and Dentistry, Moscow, Russia; e-mail: orthodont.tanghui@yandex.ru, ORCID ID https://orcid.org/0009-0005-2092-8505. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comments.

Aleksandr A. Sletov, Belgorod State National Research University

Aleksandr A. Sletov, Holder of Advanced Doctorate (D.Sc.), Professor, Department of General Dentistry,Belgorod State National Research University, Belgorod, Russia; e-mail: dr.sletov-aleksandr@yandex.ru; ORCID ID https://orcid.org/0000-0001-5183-9330. Definition of the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript, and provision of valuable comments.

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Published

28-03-2024

How to Cite

Gabbasova IV, Sletova VA, Oksentyuk AD, Abisalova IL, Gandylian KS, Ling Z, Saltovets RR, Glushanyan ZI, Ordashev HA, Shakhbanov AK, Mikhalchenko DV, Shakhbanov SA, Isaeva BR, Idrisova AA, Admakin OI, Loktionova MV, Vorobyeva OV, Hui T, Sletov AA (2024) Diagnostic analysis of toxic damage due to a dose of zoledronic acid. Research Results in Pharmacology 10(1): 45–51. https://doi.org/10.18413/rrpharmacology.10.433

Issue

Vol. 10 No. 1 (2024)

Section

Experimental Pharmacology

License

Copyright (c) 2024 Irina V. Gabbasova, Valeria A. Sletova, Alina D. Oksentyuk, Irina L. Abisalova, Kristina S. Gandylian, Zhou Ling, Roman R. Saltovets, Zhanna I. Glushanyan, Hasan A. Ordashev, Arsen K. Shakhbanov, Dmitry V. Mikhalchenko, Said A. Shakhbanov, Biyke R. Isaeva, Asiyat A. Idrisova, Oleg I. Admakin, Marina V. Loktionova, Oksana V. Vorobyeva, Tang Hui, Aleksandr A. Sletov

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