Ion channel TRPA1 is a promising therapeutic target for treatment of pain

Authors

  • E.A. Beskhmelnitsyna Regional State Budget Organization of Health Service ‘City hospital №2’
  • M.V. Korokin Belgorod State National Research University
  • T.V. Avtina Belgorod State National Research University
  • O.V. Martynova Belgorod State National Research University
  • I.I. Varavin Regional State Budget Organization of Health Service ‘Regional Oncological Center’
  • A.N. Tishin Belgorod State National Research University

DOI:

https://doi.org/10.18413/2500-235X-2015-1-4-21-24

Abstract

TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the last time information about the role of TRPA1 in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature. Given this information, the interest for search and study of pharmacological agents, which selectively blocked of TRPA1 and reduced the severity of pain and inflammation is increasing.

Keywords:

ion channel TRP, TRPA1, pain, ketorolak, nociception, analgesia, neuropathy

References

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Author Contribution

E.A. Beskhmelnitsyna, Regional State Budget Organization of Health Service ‘City hospital №2’

Gynecologist

M.V. Korokin, Belgorod State National Research University

Doctor of Medical Sciences, Professor; Department of pharmacology

T.V. Avtina, Belgorod State National Research University

PhD in Pharmaceutical Sciences, Associate Professor, Department of Pharmacology

O.V. Martynova, Belgorod State National Research University

Postgraduate student, Department of pharmacology

I.I. Varavin, Regional State Budget Organization of Health Service ‘Regional Oncological Center’

Oncologist

A.N. Tishin, Belgorod State National Research University

Postgraduate student, Department of pharmacology

Downloads

Published

30-12-2015

How to Cite

Beskhmelnitsyna E, Korokin M, Avtina T, Martynova O, Varavin I, Tishin A (2015) Ion channel TRPA1 is a promising therapeutic target for treatment of pain. Research Results in Pharmacology 1(1): 20–22. https://doi.org/10.18413/2500-235X-2015-1-4-21-24

Issue

Vol. 1 No. 1 (2015)

Section

Experimental Pharmacology

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