Correction of protein and lipid spectra of erythrocyte membranes as a pathogenetic supplement to the therapy of coronary heart disease

Authors

DOI:

https://doi.org/10.18413/rrpharmacology.11.718

Abstract

Introduction: Coronary heart disease is currently a pressing problem in the medical and scientific community. The hemic component, which is a disruption of the ability of red blood cells to effectively exchange gases, is of great importance in ischemic myocardial damage. Oxidative stress, through functional and structural changes in red blood cells, can significantly impair the efficiency of oxygen delivery to tissues.

Materials and Methods: In this clinical study, 80 patients suffering from coronary heart disease (stable angina pectoris functional class II-III) were selected. They were divided into two groups, one of which received traditional treatment, and the other – traditional treatment in combination with Mexicor. Before the start of taking the drugs and 11 days after the start of therapy, the clinical condition of the patients, bicycle ergometry indicators and the values of protein and lipid spectra of erythrocyte membranes were assessed.

Results: Addition of Mexicor, a drug with antioxidant and endothelioprotective properties, to the classical approach to therapy resulted in correction of various clinical parameters by values from 11% to 58.82%; bicycle ergometry – from 20.29% to 70.31%; protein spectrum of erythrocyte membranes – from 3.08% to 75.41%; and lipid spectrum – from 8.67% to 35.83%. Moreover, most of the studied parameters statistically significantly differed from those both in the control group and the traditional treatment group.

Conclusion: The combination of traditional treatment with single daily intravenous injections of 5 mL of Mexicor(ethylmethylhydroxypyridine succinate 50 mg/mL), made it possible not only to improve the clinical course and functional indicators, but also to positively influence the pathogenetic causes of ischemia development through significant, statistically reliable correction of the indicators of the protein and lipid spectrum of red blood cell membranes.

Graphical Abstract

Keywords:

oxidative stress, cardiovascular diseases, clinical trial, Mexicor, antioxidant

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Author Contribution

Svetlana G. Dorofeeva, Kursk State Medical University

Assistant of the Department of Propaedeutics of Internal Diseases, Kursk State Medical University, Kursk, Russia; e-mail: Swet.naumova@yandex.ru; ORCID ID: https://orcid.org/0009-0008-1507-0569. The author had the primary role in the data collection, statistical data processing, analysis, and interpretation of the study results, prepared a draft version of the article, and translated the final version of the article into English.

Eugenia N. Konoplya, русский

Doctor of Medical Sciences, Professor of the Department of Propaedeutics of Internal Diseases, Kursk State Medical University, Kursk, Russia; e-mail: Konopljaen@kursksmu.net; ORCID ID: https://orcid.org/0009-0002-6861-3500. The author was the research program supervisor and contributed to the concept of the study.

Oksana V. Mansimova, русский

Candidate of Medical Sciences, Associate Professor of the Department of Propaedeutics of Internal Diseases, Kursk State Medical University, Kursk, Russia; e-mail: manoks555@mail.ru; ORCID ID: https://orcid.org/0009-0000-6689-4797. The author contributed to the data collection and statistical processing.

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Published

01-07-2025

How to Cite

Dorofeeva SG, Konoplya EN, Mansimova OV (2025) Correction of protein and lipid spectra of erythrocyte membranes as a pathogenetic supplement to the therapy of coronary heart disease. Research Results in Pharmacology 11(3): 1–9. https://doi.org/10.18413/rrpharmacology.11.718

Issue

Vol. 11 No. 3 (2025)

Section

Clinical Pharmacology

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Copyright (c) 2025 Dorofeeva SG, Konoplya EN, Mansimova OV

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