The effect of the composition of Soderm®-Forte gel and the new injectable form of Rexod® on pathology findings in gingival tissue in experimental periodontitis in rats

Pavel A. Galenko-Yaroshevsky; Valeriy K. Leontev; Aleksandr А. Slavinskiy; Kristina V. Tseluiko; Mark A. Zadorozhniy; Sergey S. Todorov; Viktor L. Popkov; Svetlana A. Lebedeva; Anait V. Zelenskaya; Andrey V. Zadorozhniy; Aleksandr A. Verevkin

doi:10.3897/rrpharmacology.8.98809

Authors

Pavel A. Galenko-Yaroshevsky Kuban State Medical University; Research Institute of Pharmacology of Living Systems of Belgorod National Research University https://orcid.org/0000-0001-6856-1777
Valeriy K. Leontev Belgorod National Research University; A.I. Yevdokimov Moscow State University of Medicine and Dentistry https://orcid.org/0000-0003-2296-8904
Aleksandr А. Slavinskiy Kuban State Medical University https://orcid.org/0000-0001-9824-9186
Kristina V. Tseluiko Rostov State Medical University https://orcid.org/0000-0001-6856-1777
Mark A. Zadorozhniy Rostov State Medical University https://orcid.org/0000-0002-7528-6109
Sergey S. Todorov Rostov State Medical University https://orcid.org/0000-0001-8476-5606
Viktor L. Popkov Kuban State Medical University https://orcid.org/0000-0001-7362-0073
Svetlana A. Lebedeva I.M. Sechenov First Moscow State Medical University https://orcid.org/0000-0003-0325-6397
Anait V. Zelenskaya Kuban State Medical University https://orcid.org/0000-0001-9512-2526
Andrey V. Zadorozhniy Rostov State Medical University https://orcid.org/0000-0001-9552-8542
Aleksandr A. Verevkin Kuban State Medical University https://orcid.org/0000-0002-4159-2618

DOI:

https://doi.org/10.3897/rrpharmacology.8.98809

Abstract

Introduction: Periodontitis is the most important problem of modern dentistry. The development of new medicines and treatment regimens for patients with periodontal complex lesions is a strategic direction of modern pharmacology and dentistry. In this view, pride of place goes to morphological research, which allows not only to study the effect of drugs on pathomorphological changes in periodontal tissues, but also to estimate their therapeutic effectiveness. Aim of the study: to determine the nature of the effect of the composition of Soderm®-Forte gel and the new injectable form of Rexod® on the pathology findings in gingival tissue of rats with experimental periodontitis.

Materials and methods: Experimental periodontitis (EP) was induced in rats by ligature method. The study was performed according to the following algorithm: animals with intact periodontium; animals with untreated EP; animals with EP treated with traditional drug therapy (TDT); animals with EP treated with combinations of TDT with Soderm®-Forte gel and TDT with Soderm®-Forte gel and the new injectable form (NIF) of Rexod®. For pathomorphological examination, biopsy specimen was taken from the gingival margin of the lower incisors. The ImageJ software was used for computer morphometry.

Results and discussion: Examination of the gum samples revealed moderate therapeutic effects of the TDT. The combinations of TDT with Soderm®-Forte gel and, to a greater extent, TDT with Soderm®-Forte gel and the NIF of Rexod® showed high pharmacotherapeutic efficacy, manifested in rapid regeneration of the gingival tissues.

Conclusion: The combination of TDT, Soderm®-Forte gel and the NIF of Rexod® shows the most beneficial effect on the pathological processes in the gum. The pharmacotherapeutic effect of the studied combination promotes the earliest regeneration of damaged gum tissues and reduces the risk of persistent pathology changes in them.

Keywords:

Soderm®-Forte gel, computer morphometry, new injectable form of Rexod®, pathology findings, gingival tissues, experimental periodontitis

Author Contribution

Pavel A. Galenko-Yaroshevsky, Kuban State Medical University; Research Institute of Pharmacology of Living Systems of Belgorod National Research University

corresponding member of the Russian Academy of Sciences, Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor, Head of the Department of Pharmacology.

Valeriy K. Leontev, Belgorod National Research University; A.I. Yevdokimov Moscow State University of Medicine and Dentistry

member of the Russian Academy of Sciences, Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor of Medicine and Dentistry, Vice-President of the Dental Association of Russia, Honored Scientist of the Russian Federation, laureate of the State Prize of the Russian Federation in Science and Technology.

Aleksandr А. Slavinskiy, Kuban State Medical University

Holder of an Advanced Doctorate (Doctor of Science) in Biological Sciences, Professor, Head of the Department of Pathological Anatomy.

Kristina V. Tseluiko, Rostov State Medical University

Postgraduate student of the Department of Pediatric Dentistry.

Mark A. Zadorozhniy, Rostov State Medical University

Postgraduate student of the Department of Dentistry No.1.

Sergey S. Todorov, Rostov State Medical University

Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences; pathoanatomist, Head of the Morphological Department.

Viktor L. Popkov, Kuban State Medical University

Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor, Department of Orthopedic Dentistry.

Svetlana A. Lebedeva, I.M. Sechenov First Moscow State Medical University

Holder of an Advanced Doctorate (Doctor of Science) in Biological Sciences, Professor, Department of Pharmacology.

Anait V. Zelenskaya, Kuban State Medical University

PhD in Medical Sciences, Associate Professor of the Department of Pharmacology.

Andrey V. Zadorozhniy, Rostov State Medical University

hD in Medical Sciences, Associate Professor, Head of the Department of Dentistry No.4.

Aleksandr A. Verevkin, Kuban State Medical University

PhD in Medical Sciences, Associate Professor, Department of Pathological Anatomy.