Pharmacological correction of endothelial dysfunction using ademethionin and taurine

Authors

  • Taisiya A. Khadiyeva Belgorod State National Research University
  • Tatyana G. Pokrovskaya Belgorod State National Research University
  • Yuliya V. Belousova Moscow Institute of Physics and Technology

DOI:

https://doi.org/10.3897/rrpharmacology.5.32730

Abstract

Introduction: Рharmacological correction of endothelial dysfunction is a urgent problem of modern medicine.

Materials and methods: Endothelial dysfunction was simulated in male rats using the e-NOS inhibitor L-NAME (25 mg/kg/day intraperitoneally, for 7 days). Simulation of ADMA-like preeclampsia was performed by intraperitoneal injection of L-NAME to females in the same doses for 7 days (14-20th days of pregnancy). These pathologies were corrected by administering ademethionine in dose 150 mg/kg and taurine at a dose of 260 mg/kg, as well as their com­bination at the same doses, intragastrically, through an atraumatic probe, once a day.

Results: In the group with use of taurine at a dose of 260 mg/kg the coefficient of endothelial dysfunction decreased to the level of intact animals. Use of ademethionine at a dose of 150 mg/kg and taurine at a dose of 260 mg/kg combined resulted in the most pronounced endothelioprotective effect on the ADMA-like preeclampsia model. The coefficient of endothelial dysfunction decreased more than when using monotherapy of these drugs. Morphological studies of myo­cardiocytes showed that the combination of ademethionine at a dose of 150 mg/kg and taurine at a dose of 260 mg/kg prevented an increase in the cross-section of cardiomyocytes.

Discussion: Possibly, ademethionine and taurine have an endothelioprotective effect because of their ability to decrease hyperhomocysteinemia.

Conclusion: The investigated drugs showed pronounced endothelioprotective activity and can be recommended for further pre-clinical studies.

Keywords:

endothelial dysfunction, preeclampsia, ademethionine, taurine, nitrogen oxide, homocysteine

Author Contribution

Taisiya A. Khadiyeva, Belgorod State National Research University

Postgraduate student, Department of Pharmacology and Clinical Pharmacology.

Tatyana G. Pokrovskaya, Belgorod State National Research University

Professor, Department of Pharmacology and Clinical Pharmacology.

Yuliya V. Belousova, Moscow Institute of Physics and Technology

Magister of the Faculty of Medical and Biological Physics.

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Published

19-04-2019

How to Cite

Khadiyeva TA, Pokrovskaya TG, Belousova YV (2019) Pharmacological correction of endothelial dysfunction using ademethionin and taurine. Research Results in Pharmacology 5(2): 13–21. https://doi.org/10.3897/rrpharmacology.5.32730

Issue

Section

Review article

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