Endothelioprotective property of the combination of the thioctic acid and rosuvastatin shown in the endothelial dysfunction models

Authors

  • Olga Viktorovna Molchanova Belgorod Oncological Clinic
  • Tatyana G. Pokrovskaya Belgorod National Research University
  • Sergej V. Povetkin Kursk State Medical University
  • Konstantin M. Reznikov Voronezh State Medical University named after N.N. Burdenko

DOI:

https://doi.org/10.18413/2313-8971-2016-2-1-9-15

Abstract

During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7 days, and the same of female rats was performed by bilateral ovarioectomy and further intraperitoneal administration of L-NAME at a dose of 25 mg/kg for 7. The deficiency of nitric oxide as a result of the NO-synthase blockade was accompanied by the impairment of the endotheliumdependent and independent vasodilatation estimated in the pharmacological tests, which was expressed in the increasing coefficient of endothelial dysfunction. As a result of the research it was discovered that the combined application of thioctic acid at a dose of 50 mg/kg/day with antioxidant features and rosuvastatin at a dose of 0.85 mg/kg/day, which is a lipid-lowering drug, has endothelioprotective effect on the models of L-NAME-induced and hypoestrogen-LNAME-induced deficiency of nitric oxide, which is expressed in prevalence of endotheliumdependent relaxations of vessels and decreasing coefficient of endothelial dysfunction, as well as prevention of increase in nitric oxide production.

Keywords:

L-NAME, endothelial dysfunction, thioctic acid, rosuvastatin, nitric oxide, oxidative stress, ovarioectomy

Author Contribution

Olga Viktorovna Molchanova, Belgorod Oncological Clinic

Doctor of the ultrasonic diagnostics. Belgorod Oncological Clinic, Belgorod, Russia 

Tatyana G. Pokrovskaya, Belgorod National Research University

Doctor of Medical Sciences, Professor; Department of pharmacology of Belgorod State National Research University, Belgorod, Russia

Sergej V. Povetkin, Kursk State Medical University

Doctor of Medical Sciences, Professor; Department of Clinical Pharmacology and Pharmacotherapy Kursk State Medical University, Kursk, Russia 

Konstantin M. Reznikov, Voronezh State Medical University named after N.N. Burdenko

Doctor of Medical Sciences, Professor Department of Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Russia 

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Published

31-03-2016

How to Cite

Molchanova OV, Pokrovskaya TG, Povetkin SV, Reznikov KM (2016) Endothelioprotective property of the combination of the thioctic acid and rosuvastatin shown in the endothelial dysfunction models. Research Results in Pharmacology 2(1): 9–15. https://doi.org/10.18413/2313-8971-2016-2-1-9-15

Issue

Section

Review article

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